Intestinal permeability, also called a leaky gut, may trigger digestive concerns like bloating, abdominal discomfort, or irregular digestion. It may compromise your gut lining and allow harmful substances to pass into your bloodstream, triggering inflammation and digestive issues. Gut repair supplements could help address these concerns by restoring gut barrier integrity, reducing inflammation, and rebalancing your gut microbiome. These effects may help support gut and digestive health while also minimizing potential gut-related issues.
In this article, we discuss the 10 best gut repair supplements of 2025, carefully selected based on ingredient quality, scientific support, and user experiences.
Terra Origin's Healthy Gut Powder may provide digestive support, maintain a strong intestinal lining, and boost energy levels. It includes ingredients like L-glutamine and N-acetyl-D-glucosamine, which might help minimize digestive discomfort and bloating.Healthy Gut Powder also features a zinc carnosine (PepZinGI®) compound that may work with quercetin dihydrate and copper to decrease intestinal damage and inflammation. MSM and aloe vera extract are also included to help soothe the gut lining and ease digestion.
The makers state that Terra Origin Healthy Gut Powder is free from harmful additives, such as dairy, sugar, and GMOs. The powder comes in berry, peach banana, matcha green tea, honey lemon, mint, watermelon, chocolate, and green apple flavors.
The brand Codeage claims that its Leaky Gut Formula could support microbial balance and intestinal function. It contains ingredients like butyric acid, which is a short-chain fatty acid that may serve as fuel for colon cells.
Codeage's Leaky Gut Formula also includes zinc L-carnosine and vitamin D3 (cholecalciferol). Zinc L-carnosine may support mucosal lining repair, while vitamin D3 might contribute to better immunity against pathogens by supporting epithelial barrier function.
For added digestive comfort, the Leaky Gut Formula includes soothing botanicals like deglycyrrhizinated licorice (DGL), slippery elm, chamomile, ginger root, and cinnamon. These ingredients may help calm gut irritation and support the digestive tract lining.
The makers suggest taking two Leaky Gut Formula capsules every day with 8 ounces of water or your favorite beverage. It may be taken with or without food.
Liver Medic's Leaky Gut Repair may help tackle gut permeability rather than mask symptoms. Its 2-capsule serving contains 981.26mg of a proprietary gut repair blend, which comprises ingredients like organic marshmallow root, slippery elm, L-glutamine, licorice root extract, and more.
The makers state that Liver Medic Leaky Gut Repair avoids the use of additives like microcrystalline cellulose and magnesium stearate, which may otherwise interfere with nutrient absorption or digestive function.
According to its official site, Liver Medic's Leaky Gut Repair is made in facilities that meet cGMP and NSF certification standards. These certifications could indicate that Leaky Gut Repair may support gut health while prioritizing safety and ingredient quality.
Seed's DS-01 Daily Synbiotic may improve gut immunity and digestion. Its 2-capsule serving provides 53.6 billion AFU (Active Fluorescent Units) from 24 probiotic strains, which could help optimize the body's natural gut microbiome.
DS-01 Daily Synbiotic by Seed could support bowel regularity and reduce bloating. It includes prebiotics like pomegranate-derived polyphenols. Your gut microbes may biotransform these polyphenols into beneficial metabolites to support and maintain gut lining integrity.
The makers state that DS-01 Daily Synbiotic features ViaCap® Delivery Technology, which ensures the probiotics remain viable as they pass through your digestive tract. The outer prebiotic capsule adds an extra layer of protection, shielding the probiotics from oxygen, moisture, and heat, preserving their potency until they reach the colon.
Seed's DS-01 Daily Synbiotic offers a subscription model for purchase, costing $49.99 per month for a 30-day supply. The subscription also includes free shipping within the US and comes with a 30-day risk-free guarantee.
As per its official site, each 2-capsule serving of Ancient Nutrition's Leaky Gut features 563mg of a mushroom and probiotic blend, 700mg of gut integrity botanical blend, and 6mg of zinc. The gut integrity botanical blend comprises ingredients like fermented astragalus root, cardamom seed, licorice root, marshmallow root, and L-glutamine to support healthy gut function.
Leaky Gut by Ancient Nutrition contains ingredients like lion's mane mushrooms and 2 billion CFU of Bacillus coagulans. These ingredients have anti-inflammatory effects that may help calm gut irritation and support digestive processes.
Ancient Nutrition's Leaky Gut comes in capsule form, providing 60 capsules per bottle for a 30-day supply. The makers suggest taking 2 Ancient Nutrition Leaky Gut capsules daily with water of your preferred beverage.
As per its official site, Naked Gut by Naked Nutrition features seven gut-support ingredients, including DE111® probiotic strain (Bacillus subtilis), glutamine, and licorice root powder. It also includes prebiotic fibers like acacia fiber, citrus pectin, and inulin, which may help support a healthy gut microbiome balance.
Naked Gut could support efficient digestion and nutrient absorption, helping your body process and utilize proteins, fats, carbohydrates, and essential nutrients more efficiently. This might contribute to improved daily energy levels, performance, and gut health.
The makers suggest mixing one scoop (6g) of Naked Gut powder into 8 ounces of water, juice, or a smoothie and drinking the mixture once per day. It can be consumed with or without food.
Well Of Life's Gut Repair 360 could help target the gut lining and promote the integrity of the intestinal barrier. These processes may help protect the gut against harmful pathogens and support better nutrient absorption and digestion.
An imbalanced gut environment might contribute to symptoms like bloating, gas, skin flare-ups, joint discomfort, and fatigue. Gut Repair 360 might help alleviate these concerns by supporting a more balanced internal ecosystem with ingredients like fennel seed extract, fulvic acid, slippery elm, and amylase.
The makers suggest taking one Well Of Life Gut Repair 360 capsule three times daily with water, preferably alongside meals. Through its official website, one bottle of Gut Repair 360 is available at a one-time purchase price of $49.
Intestinal Fortitude GLR-6 may promote digestive health by decreasing inflammation and supporting your gut's protective barrier. It features ingredients like L-glutamine, which may help fuel your intestinal cells and enhance gut integrity. N-acetyl glucosamine (N-A-G) could help support the regeneration of the gut lining.
Other ingredients in Intestinal Fortitude GLR-6, like slippery elm and marshmallow root, could help soothe gut irritation, while DGL Licorice Root may speed up the repair of the stomach lining. Fenugreek could further reduce inflammation and support gut health.
As per the makers, Intestinal Fortitude's GLR-6 is made in the USA in a GMP-certified facility under strict manufacturing and quality control standards. Each bottle contains 120 capsules, with the maker's recommended serving of four capsules per day.
Nuven Naturals' Gut Health pairs probiotics, prebiotics, and plant-based ingredients to support a balanced gut microbiome. Its 2-capsule serving may provide a prebiotic blend of 75mg each of the prebiotic inulin from chicory root and agave. It also features 560 mg of a herbal blend with ingredients like fenugreek seed, turmeric root, ginger root, licorice, and marshmallow root.
The Nuven Naturals Gut Health formula also comprises 72mg of a probiotic blend (with 10 billion CFU). These probiotics may introduce live microorganisms that could help restore and maintain microbiome balance, which is essential for proper digestion and gut health.
Gut repair supplements with probiotics and prebiotics may change the bacterial balance in the digestive tract. When your gut bacteria begin to ferment prebiotics in gut repair supplements, gases like hydrogen, methane, and carbon dioxide are produced.
The fermentation process might contribute to symptoms like abdominal pressure, bloating, cramping, and flatulence. These side effects are more pronounced if you have sensitive digestive systems or are new to high-fiber or probiotic supplements.
Gut repair supplements frequently alter bowel regularity, which may trigger diarrhea, constipation, or fluctuating bowel patterns. These changes are typically due to your body's reaction to ingredients in gut repair supplements like soluble fibers (e.g., inulin, acacia fiber), digestive enzymes, or osmotic laxatives (like magnesium citrate or aloe vera).
The gut repair supplements may also cause your stool to soften or loosen, resulting in increased frequency or urgency. It is more common during the early adjustment period as your gut microbiota shifts and digestive transit times change.
Gut repair supplements may also trigger constipation, particularly if they have a high concentration of collagen or proteins.
Gut repair supplements with collagen may cause potential allergic reactions, which might range from mild symptoms like nausea, skin rashes, and bloating to more serious effects like itching, swelling, or respiratory issues in users with fish or beef allergies.
Although rare, allergic reactions could also manifest as headaches, joint stiffness, or gastrointestinal upset. If you have food intolerances, you may further experience a histamine response to gut repair supplements.
Some ingredients in gut repair supplements, such as magnesium citrate, aloe vera, or cascara sagrada, may act as natural laxatives or bowel stimulants. These ingredients might contribute to excessive water loss through the intestines.
Frequent bowel movements (especially if watery or unformed) after using gut repair supplements may deplete electrolytes like sodium, potassium, and magnesium. Electrolyte imbalance may trigger symptoms like fatigue, muscle cramps, headaches, dizziness, irregular heartbeat, and, in severe cases, fainting or confusion.
In evaluating the best gut repair supplements, we considered price and value as major factors. We focused on finding supplements that offer effective gut health support without being overly expensive. Nuven Naturals' Gut Health offers an affordable choice, which is priced at $21.99 for 120 capsules, working out to $0.18 per capsule.
Similarly, Naked Nutrition's Naked Gut costs $24.99 for a 240g bottle containing 40 servings. It could provide a budget-friendly gut repair supplement for users who prefer powders over capsules. Ancient Nutrition's Leaky Gut is priced at $29.95 for 60 capsules, offering mid-value.
Codeage's Leaky Gut Formula and Liver Medic's Leaky Gut Repair are both priced at $29.99 for 60 capsules, which comes to $0.50 per capsule. Both these supplements may offer a good balance of affordability and targeted gut repair.
Intestinal Fortitude's GLR-6 costs $39.99 for 120 capsules, offering a suitable option for gut repair, though it is slightly more expensive than the options mentioned above. Terra Origin's Healthy Gut Powder costs $35.99 for a 243g bottle (30 servings).
Well Of Life's Gut Repair 360 is priced at $49 for 90 capsules, which works out to $0.54 per capsule. It provides a balanced formula for comprehensive gut repair at a reasonable price.
On the premium end, DS-01 Daily Synbiotic by Seed costs $49.99 for 60 capsules ($0.83 per capsule). Happy Mammoth's Prebiotic Collagen Protein is the most expensive gut repair supplement on the list at $69.99 for a 360g bottle (24 servings), working out to a cost of $2.92 per serving.
In evaluating the brand reputation of the best gut repair supplements, we assessed each company's standing based on Trustpilot and BBB ratings, the number of complaints, and consumer trust and accountability.
Terra Origin and Codeage have the strongest brand reputation. Terra Origin holds a 4.5/5 Trustpilot rating from over 2,100+ reviews, reflecting widespread customer satisfaction. Codeage follows closely with a 4.2/5 Trustpilot rating, though it's based on only 60 reviews, which may not fully reflect its brand perception. Still, Codeage holds an A grade from the Better Business Bureau (BBB) and has just two complaints filed, which may indicate reliable service and accountability.
Similarly, Liver Medic also ranks high with a 4.5/5 Trustpilot score, although it lacks a BBB rating, which could raise some concerns about its credibility. The Seed brand has received an A- rating from BBB with 35 complaints and a lack of verified Trustpilot profile.
Ancient Nutrition has an A+ from BBB, showing good business practices, but its 3/5 Trustpilot rating reveals mixed customer experiences. Despite a 4.2/5 Trustpilot score from 9810+ review users, Happy Mammoth is held back by a D- BBB rating and 255 complaints, pointing to service-related issues.
Naked Nutrition's F rating on BBB and 29 unresolved complaints raise major concerns. Well of Life shares the same F rating on BBB, and both Naked Nutrition and Well of Life have no Trustpilot presence.
On the lower end of the spectrum, Nuven Life and Intestinal Fortitude brands remain unrated on Trustpilot and BBB. They offer little third-party validation or consumer insight, causing speculations as to their credibility.
When evaluating the best gut repair supplements, the refund policy duration may affect customer satisfaction and confidence. Intestinal Fortitude provides a 120-day money-back guarantee, offering a long window to assess GLR-6's effectiveness. Customers can return unopened bottles for a refund, though shipping costs are non-refundable.
Well Of Life offers a 60-day return policy while providing a tracking number for returns, ensuring a transparent and smooth refund process. Happy Mammoth matches this with a 60-day guarantee, but it requires that consumers take at least 9 servings of its Prebiotic Collagen Protein alongside a healthy diet.
Terra Origin provides a 30-day return period, free return shipping, and quick refunds, which could make its Healthy Gut Powder a customer-friendly choice. Seed provides a 30-day refund policy for first-time buyers, offering a full refund minus shipping, VAT, and duties.
Codeage offers a 30-day policy, but it limits refunds to just one item per order and excludes sale items. Ancient Nutrition also offers a 30-day refund guarantee but requires prior contact with customer service for returns, which may sometimes cause delays.
Nuven Naturals backs its Gut Health products with a 30-day refund policy, providing customer support for returns. Naked Nutrition has a relatively short 14-day return window, and the need for a special return label adds some complexity.
However, Liver Medic's refund policy is the least transparent, as the details are not disclosed on their official website, which could deter potential buyers.
Gut repair supplements may help maintain gut lining integrity and a balanced gut microbiome. This is important as disruptions in these processes may contribute to inflammation, nutrient malabsorption, and gastrointestinal discomfort like bloating, cramps, or nausea.
The gut repair supplements featured in the article contain ingredients such as L-glutamine, N-acetylglucosamine, probiotics, and zinc carnosine. These compounds could help support gut barrier function, reduce irritation, and help restore microbial balance.
However, gut repair supplements may trigger side effects like temporary bloating, gas, or changes in bowel habits. Gut repair supplements with ingredients like magnesium or aloe vera may contribute to loose stools or mild electrolyte disturbances.
Besides using gut repair supplements, consuming a diet rich in fiber from vegetables, fruits, and whole grains may nourish beneficial gut bacteria and promote healing. Adding fermented foods like yogurt, kefir, kimchi, or sauerkraut to your diet may also benefit gut health.
You should use gut repair supplements alongside some healthy habits, such as staying hydrated, refraining from processed and sugary foods, and reducing stress through practices like meditation or gentle exercise. When paired with gut repair supplements, these habits may help contribute to long-term gut health support.
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