Berberine might support individuals with conditions like type 2 diabetes and metabolic syndrome. It might help lower blood sugar, cholesterol, and blood pressure. Berberine could also help slow the progression of diabetes and cardiovascular diseases by improving insulin resistance, hyperlipidemia, and glucose intolerance.
In this guide, you will learn about the potential health benefits and side effects of berberine. You will also learn about the evidence supporting its use, along with safety and quality considerations. We will also highlight the Best 5 berberine supplements available in 2024 to help you make an informed decision.
Berberine is recognized for its potential health benefits, particularly in metabolic health. It is primarily extracted from plants such as barberry, goldenseal, Oregon grape, and Chinese goldthread.
Berberine is known to support metabolic function, which includes regulating blood sugar levels and managing cholesterol. It has a bright yellow color and has been used in traditional medicine for a long time, especially in Chinese and Ayurvedic practices.
Berberine may help lower blood sugar levels, which could be beneficial for people with type 2 diabetes. It might also improve cholesterol levels by lowering bad cholesterol (LDL) and triglycerides. It may support weight loss and promote heart health by potentially lowering blood pressure.
Berberine may work by activating an enzyme called AMP-activated protein kinase (AMPK), which may help in managing energy and metabolism in the body. When activated, AMPK may improve how the body uses insulin and supports metabolic health.
You can also find berberine as a supplement, usually in capsules or tablets, with the most common form being berberine hydrochloride (HCl). Some Berberine Supplements might use a form that enhances absorption.
As per research, people are given between 500 mg and 1500 mg of berberine per day. Under some circumstances, the dosage is reduced to 300mg 3 times daily if gastrointestinal issues occur.
While berberine is generally safe for most people, it could cause side effects such as stomach upset, diarrhea, or constipation.
Manufactured by NutriFlair, Premium Berberine HCL may support healthy blood sugar levels, which may potentillay help in managing insulin sensitivity and metabolic health. A combination of the antioxidant action of berberine with Ceylon cinnamon may provide support to boost your metabolism.
The lower level of coumarin in Ceylon cinnamon could make it a better alternative to cassia cinnamon. NutriFlair Premium Berberine HCL might also help balance microbial populations in the gut.
Ceylon cinnamon in their formula may regulate blood sugar, decrease cholesterol, and aid in weight management. NutriFlair Premium Berberine HCL may support your metabolism, promote healthy weight management, and maintain balanced blood sugar levels.
Berberine Hydrochloride (HCl) is a potent alkaloid that may support metabolic health by activating AMP-activated protein kinase (AMPK). It may help in regulating glucose and lipid metabolism. Berberine HCl exhibits free-radical-fighting activity and supports immune system function, promoting overall well-being.
Its unique properties may help maintain proper microbial balance in the gut, contributing to gastrointestinal health. Research has indicated that berberine HCl can lead to significant improvements in cholesterol and lipid levels.
Ceylon cinnamon is rich in antioxidants and exhibits potent anti-inflammatory properties. It may help boost metabolic rate, which could support weight management and enhance energy levels, possibly due to its effect in improving the insulin sensitivity. Cinnamon might lower levels of low-density lipoprotein (LDL) cholesterol, contributing to better heart health. Cinnamon might help lower fasting blood sugar levels and enhance insulin sensitivity. It could also help in slowing down the digestion process, which might regulate blood sugar spikes after meals.
As per the official website, Berberine By We Like Vitamins claims to support metabolic health.
It may help in supporting blood sugar levels and enhance insulin sensitivity.
Berberine By We Like Vitamins may also promote cardiovascular health by helping to manage healthy cholesterol levels, reducing LDL (bad cholesterol) while increasing HDL (good cholesterol). It claims to support digestive health by supporting a balanced gut microbiome and improving digestion.
The makers mention that regular Berberine By We Like Vitamins usage may help with improved blood sugar levels, reduced cravings, and overall better health.
Each Berberine By We Like Vitamins serving consists of two capsules and delivers a high potency of 1200 mg of Berberine HCl.
It could be purchased through the official website, as a one-time order, or through a subscription to save on future purchases, with free shipping on orders over $99. Berberine By We Like Vitamins also comes with a 60-day money-back guarantee, which may help you to try it risk-free.
As per the official website, Toniiq Ultra High Strength Berberine HCL aims to use a special extraction process for a highly pure Berberine. This process may help keep the powerful properties of the berberine while maintaining high purity standards. They state that their Berberine 97% comes from the Himalayan Berberis aristata root (Indian barberry). Each 500 mg serving provides an 82:1 concentration of active compounds, which may help ensure its effectiveness. However, a highly concentrated Toniiq Ultra High Strength Berberine HCL could cause some stomach problems. As per the official website, Toniiq Ultra High Strength Berberine HCl is priced at $29.97 but is currently available for $25.47, with an extra 15% off for subscriptions. It is suggested to take one capsule up to three times a day or as your doctor recommends. Toniiq Ultra High Strength Berberine HCL may help support healthy blood sugar levels, a healthy digestive system, and weight management. The makers claim that each batch goes through strict testing during and after production. The manufacturing facility is GMP-certified, showing the company's commitment to making high-quality supplements in the USA. As per the official website, Toniiq Ultra High Strength Berberine HCL also undergoes a third-party testing program and provides a certificate of analysis(COA) for every batch produced. However, one disadvantage is that the Toniiq Ultra High Strength Berberine HCL capsules might contain some additives like microcrystalline cellulose, vegetable magnesium stearate, and silicon dioxide.
Berberis aristata extract, derived from the Indian barberry plant, supports digestive health. It may help in alleviating gastrointestinal disorders, enhance bile flow, and promote liver function, contributing to overall digestive wellness. Its antimicrobial properties are noteworthy, as they may help in combating infections and promoting the immune system. Berberis aristata extract may improve insulin sensitivity and regulate blood sugar. It may also help reduce inflammation throughout the body, promoting overall health and well-being.
As per the official website, NOW Berberine Supplements claims to provide the potential benefits of berberine compound found in goldenseal, Oregon grape, and barberry.
NOW Berberine Supplements may provide a positive effect on blood sugar regulation, insulin sensitivity, and weight management, potentially supporting their metabolic health. It comes in a bottle of 90 softgels and is priced at $39.99.
NOW Berberine Supplements may help support glucose and lipid metabolism and include medium-chain triglycerides (MCT) oil to enhance the absorption of berberine.
Each softgel contains 400 mg of berberine HCl derived from Berberis aristata bark, along with 700 mg of MCT oil and capric acid (C10) for gastrointestinal comfort. It is said to be made in a GMP-certified facility, which may ensure high quality and safety.
Capric Acid
NOW Berberine Supplements contain 238 mg of Capric acid(C10) derived from mct oil which may help in supporting the immune system. Capric acid may contribute to improved cognitive function by providing an additional energy source for brain. It may also support bowel regularity, potentially aiding in a healthy gut.
MCT oil could positively influence gut microbiota, promoting a healthier digestive environment and aiding in nutrient absorption. The antimicrobial properties of MCT oil might help reduce harmful bacteria in the gut. MCT oil may have a favorable effect on cardiovascular health by potentially lowering total serum lipoproteins, which could reduce the risk of atherosclerosis. It may also assist in weight management by increasing feelings of fullness and boosting metabolic rates, serving as a quick energy source for physical performance. MCT oil could enhance cognitive function and mood by providing an energy source for your brain through ketone body production.
Berberine With Ceylon Cinnamon by PrimeMD helps regulate blood sugar levels, improve insulin sensitivity, support digestion, and assist in weight management. Its nutrients and herbal extracts may work synergistically with berberine, promoting overall wellness.
The combination of berberine with vitamins and minerals may optimize metabolic processes and support healthy energy levels. PrimeMD 21-in-1 Berberine contains additional ingredients that may aid in digestive health and also support the immune system.
PrimeMD emphasizes the purity and efficacy of its products, ensuring they are free from unnecessary additives. It may support your daily wellness by helping to combat cravings, manage appetite, and promote overall metabolism.
Berberine With Ceylon Cinnamon by PrimeMD contains ingredients like Green Tea extract, Turmeric, and Milk Thistle, which might assist in maintaining energy levels and boosting immunity.
It could aid in regulating blood sugar and improving gut health by promoting proper bowel movements and digestion.
Berberine With Ceylon Cinnamon by PrimeMD may facilitate appetite control and support cardiovascular health, potentially enhancing your fitness goals.
As per the official website, each bottle contains 120 capsules, with 5,279 mg of premium organic Ceylon cinnamon per serving, featuring 21 beneficial ingredients in one supercharged blend.
Berberine With Ceylon Cinnamon by PrimeMD is made in the USA with globally sourced components and is said to be free from common allergens and gluten with third-party lab-tested for quality.
Ceylon cinnamon helps improve insulin sensitivity and slows carbohydrate digestion. It may aid in lowering cholesterol levels and reducing the risk of cardiovascular diseases, promoting heart health. Ceylon cinnamon's ability to combat infections can bolster the immune system, enhancing overall health.
Green tea extract has catechins like epigallocatechin gallate (EGCG), which may support weight loss and fat burning. Research indicates that it enhances metabolism and increases energy expenditure. It may improve insulin sensitivity and might regulate blood sugar levels. Green tea extract may also help lower LDL cholesterol and reduce blood pressure, contributing to overall heart health.
Bitter melon is rich in compounds that might help mimic insulin and could help lower blood sugar levels and enhance insulin sensitivity. It contains antioxidants that might combat oxidative stress, potentially lowering chronic disease risk. Bitter melon may aid digestion and support gut health. Its anti-inflammatory properties could also help protect against inflammation-related conditions. Some research suggests that bitter melon may assist in weight management by promoting enhanced fat metabolism and curbing appetite.
Berberine, Siberian Ginseng, Licorice Root, Cayenne Powder, Fenugreek, Artichoke Leaf, Turmeric Root, Zinc, Ginger, Psyllium Husk, Milk Thistle, Garcinia Cambogia, Gymnema, Apple Cider Vinegar, Aloe Vera
Berberine may aid in blood sugar regulation by enhancing insulin sensitivity, which is crucial for allowing cells to absorb the glucose from bloodstream. Insulin hormone is made by the pancreas that facilitates this process, but in some cases, cells can become resistant to insulin, resulting in higher blood sugar levels. Berberine might improve insulin sensitivity, enabling cells to respond better to insulin and take in more glucose. This effect is largely due to the activation of an enzyme called AMP-activated protein kinase (AMPK). AMPK may act as an energy sensor in the body, and when activated by berberine, it may encourage cells to absorb more glucose and inhibit the liver's production of glucose. Berberine can effectively lower blood sugar levels after meals by increasing glucose uptake and reducing glucose production.
Berberine may help lower total cholesterol and LDL (low-density lipoprotein) levels. Elevated levels of LDL cholesterol could contribute to plaque buildup in the arteries, elevating heart disease risk. Berberine works by inhibiting the synthesis of cholesterol in the liver, specifically by reducing the activity of an enzyme called HMG-CoA reductase, which is crucial for cholesterol production. Berberine may promote the excretion of cholesterol through bile acids. It enhances the conversion of cholesterol into bile acids, leading to increased bile acid production, which helps remove cholesterol from the bloodstream and excrete it in the feces. Berberine contributes to improved heart health by lowering total cholesterol and LDL levels, as lower LDL cholesterol reduces the risk of plaque formation in the arteries and cardiovascular diseases.
Berberine may help in increasing metabolic rate and enhancing fat oxidation, which means it could help the body burn calories and fat, contributing to weight loss. It works in the activation of AMP-activated protein kinase (AMPK), which may boost the body's energy expenditure, leading to a higher metabolic rate, which helps create a caloric deficit by burning more calories than consumed. The AMPK activation may also promote the breakdown of fat stores for energy through a process called lipolysis, allowing the body to convert stored fat into usable energy. Berberine also improves insulin sensitivity and regulates blood sugar levels, helping to prevent possible insulin spikes that can help manage excess fat storage.
Berberine might inhibit the growth of harmful bacteria in the gut, helping to prevent infections and maintain a healthy gut environment. It may support the growth of beneficial bacteria, such as probiotics, which are essential for digestion and nutrient absorption. A higher population of beneficial bacteria could also compete with harmful bacteria for resources, further supporting gut health. Berberine may improve overall digestive health by maintaining this balanced microbiota, leading to better digestion and reduced bloating.
While berberine offers various health benefits, it may also come with some side effects. Some people may experience diarrhea, constipation, stomach cramps, and nausea.
Berberine may significantly lower blood sugar levels, which can be beneficial for those with high blood sugar but could lead to hypoglycemia (low blood sugar) in people already taking blood sugar-lowering medications.
It may interact with certain medications, such as antidiabetic drugs, anticoagulants (blood thinners), and medications metabolized by the liver, as it can inhibit specific liver enzymes (like cytochrome P450) that process drugs.
Although rare, some people may have an allergic reaction to berberine, resulting in symptoms such as rashes, itching, or swelling.
Some people have claimed to experience headaches or dizziness when taking berberine, especially at higher doses.
When choosing a berberine supplement, it's essential to focus on safety. The quality of these products is crucial because low-quality supplements can pose health risks. A berberine supplement that has been thoroughly tested by independent labs is usually safer than others.
It should also be made in a facility that follows Good Manufacturing Practices (GMP or cGMP) and is registered with the FDA. A good way to ensure safety is to look for supplements that independent labs have tested. These labs check the products for strength, purity, and any harmful substances.
For example, Toniqq clearly states its GMP status and provides links to both a certificate of analysis(COA) and third-party testing results on the product's webpage. These results back up the claims on the label, giving you confidence that you're getting the right amount of berberine.
Clear labeling is also important. Berberine Supplements should show details about where the ingredients come from, how much to take, and any potential allergens.
While evaluating Berberine Supplements, it is essential to look at how the supplement is taken, the right dose, and any other ingredients that might make it work better. NOW Berberine Supplements offers berberine in 400mg capsules, making it easy to adjust your dose if you experience any stomach issues. While some other Berberine Supplement brands like Toniiq and Nutraflair Premium Berberine HCL, claim to have higher potency or better absorption. You should also check the available user reviews which may give you a clear idea about Berberine Supplement effectiveness.
The cost of berberine supplements can vary significantly based on factors such as formulation, brand reputation, and additional ingredients.
On average, you might expect to pay between $20 and $75 for a month's supply, depending on quality and type.
For example, budget-friendly options like Berberine By We Like Vitamins can be found for around $17.99, which may provide a safe choice since it is third-party tested.
In contrast, premium options like NOW Berberine Supplements, known for enhanced absorption, can cost about $39.99.
While higher-priced Berberine Supplements may offer better results for some, it's essential to consider cost-effectiveness.
You should also be aware of the subscription services or bulk purchasing options available on the official website, which can provide discounts and reduce overall expenses.
When choosing a berberine supplement, convenience is also a critical aspect to consider. Many people prefer solutions that easily fit into their daily routines without disrupting their busy lives.
Look for Berberine Supplements that are available as capsules, soft gels, and liquid extracts. Capsules could provide you with a simple dose routine and ease of use.
The Berberine supplements we evaluated in this guide are available in capsules and softgel forms, which may help you follow the dosage routine and stay consistent with it without making any additional adjustments to your schedule.
Choosing a suitable berberine supplement may affect your health journey, especially if you want to improve how your body uses energy, manage blood sugar levels, or support heart health.
The five berberine supplements mentioned in this guide have been evaluated for their quality, effectiveness, and safety.
Each berberine supplement may provide different benefits, like better absorption, extra herbal support, or organic ingredients.
However, it's important to talk to your doctor before starting with berberine supplements, especially if you are taking sugar medications or have any other health issues.
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