Metagenics is a supplement brand that formulates vitamins, minerals, probiotics, omega‑3s, and herbal blends. It follows a functional framework, which involves supporting the body as a system and addressing underlying factors such as inflammation, nutrient imbalances, hormonal fluctuations, or gut microbiome disruption.
Metagenics offers a comprehensive multi-category range, tailored to diverse fitness needs. Its product lines include options like multivitamins, probiotics, fish oils/omega‑3s, herbal, and targeted supplements.
This review will provide an overview of Metagenics, along with its advantages and potential limitations. We will also evaluate Metagenics based on its brand reputation, consumer feedback, and how it performs in comparison to similar brands.
As per the official website, Metagenics follows the concept of personalized nutrition and has built its philosophy around the principles of functional and integrative medicine. The brand claims to provide an extensive range of products that provide targeted support for metabolic health, immune function, hormonal balance, detoxification, and gastrointestinal wellness.
Metagenics features different products, including PhytoMulti®, UltraFlora® probiotics, OmegaGenics® fish oils, and Estrovera® for menopause support.
The brand claims that all its products have rigorously tested ingredients, many of which are non-GMO, gluten-free, and suitable for vegetarians.
Metagenics is also known for its ethical and environmental commitment. In 2022, the company became a Certified B Corporation, reflecting its adherence to high standards in sustainability, transparency, and social responsibility. They ensure responsible sourcing of ingredients, pharmaceutical-grade manufacturing standards, and full label transparency.
Metagenics Vitamin D3 + K (10,000 IU) may support your immune function, bone strength, and cardiovascular health. It provides 250 mcg (10,000 IU) of vitamin D3 per softgel, a potent form of cholecalciferol that has a critical role in calcium absorption, immune system regulation, and muscle function. This formula also includes two key forms of vitamin K2, such as general vitamin K2 (20 mcg) and menaquinone-7 (MK-7) at 90 mcg per softgel.
Vitamin K2 in Vitamin D3 + K (10,000 IU) may help regulate calcium by directing it to where it's needed, like bones and teeth, and preventing it from accumulating in your arteries or soft tissues, which supports cardiovascular health. MK-7, in particular, activates osteocalcin (for bone mineralization) and matrix GLA protein (which inhibits arterial calcification), making it a crucial nutrient for both bone density and heart protection.
According to the official website, Metagenics OmegaGenics® EPA-DHA 720 may support heart, brain, joint, and immune health. It contains 430 mg EPA (eicosapentaenoic acid) and 290 mg DHA (docosahexaenoic acid), providing 720 mg of essential omega-3 fatty acids per capsule. These fatty acids are derived from sustainable sources of cold-water fish, including anchovy, sardine, and mackerel, ensuring both environmental responsibility and product purity.
Metagenics OmegaGenics® EPA-DHA 720 is carefully purified and tested for more than 200 contaminants, including heavy metals like mercury, as well as PCBs and dioxins.
The brand claims to use a proprietary stabilization process with antioxidants such as vitamin E, mixed tocopherols, rosemary extract, and ascorbyl palmitate in Metagenics OmegaGenics® EPA-DHA 720 to preserve the oil's freshness and prevent oxidation.
To further enhance the user experience, the makers added a natural lemon-lime flavor to help eliminate the fishy aftertaste that is commonly associated with fish oil supplements.
Metagenics claims that its PhytoMulti Multivitamin with Phytonutrients can provide comprehensive nutritional support and may boost your energy levels, immune health, and healthy aging.
PhytoMulti Multivitamin with Phytonutrients delivers a comprehensive blend of over 20 essential vitamins and minerals, which include vitamin A, B Vitamins, calcium, and magnesium.
Vitamin A helps in maintaining healthy vision, supporting immune defense, and promoting proper cell growth. It may also contribute to the health of skin and mucous membranes, which work as barriers against infections.
The PhytoMulti Multivitamin formula combines B vitamins like B6 and B12, which may promote energy production and nervous system function. Vitamin B6 supports neurotransmitter synthesis and helps regulate mood, while B12 aids in red blood cell formation and may help reduce fatigue. Pantothenic acid, or vitamin B5 in PhytoMulti Multivitamin, may further support energy metabolism and the synthesis of hormones and cholesterol.
The makers also added essential minerals like calcium and magnesium in PhytoMulti Multivitamin, which might contribute to strong bones and proper muscle function. Calcium may help in maintaining bone density, while magnesium sustains nerve signaling, muscle relaxation, and energy production. This formula also has zinc and selenium, which are vital antioxidants that could protect cells from oxidative stress, support immune health, and aid in wound healing. Molybdenum in PhytoMulti Multivitamin may help in breaking down amino acids and detoxifying your body.
According to the official website, Metagenics Magnesium Glycinate may help in muscle function, nerve transmission, energy production, and maintaining healthy heart and bone function. It could support muscle and nerve relaxation, which can help ease tension and reduce cramps. It may also contribute to stress management and promote calmness, aiding in maintaining healthy sleep-wake cycles.
As per the makers, Metagenics Magnesium Glycinate supports the production of the melatonin hormone, which functions by regulating sleep, thereby helping improve the quality of your rest.
UltraFlora Balance Probiotic by Metagenics may support digestive and immune function. It may work by promoting a balanced gut microbiome, which helps support the immune system naturally.
As per the official website, UltraFlora Balance Probiotic includes Lactobacillus acidophilus NCFM® and Bifidobacterium lactis Bi-07®. These strains are known for their ability to help restore and maintain a healthy, beneficial bacteria balance in your digestive tract.
UltraFlora Balance Probiotic contains a proprietary blend that delivers 15 billion colony-forming units (CFU) per capsule, supported by microcrystalline cellulose and vegetable-based capsule material to ensure purity and stability.
HerWellness Estrovera by Metagenics may support women experiencing perimenopause and menopause. This formula may provide relief from common symptoms, such as hot flashes, exessive sweat, sleep disturbances, mood swings, fatigue, and urinary and vaginal discomfort.
As per the official website, HerWellness Estrovera includes ERr 731®, which works by balancing estrogen receptors, helping to decrease the intensity of hot flashes and other hormonal symptoms. The makers suggest taking one HerWellness™ Estrovera® tablet daily with food, and the product is available in a 30-capsule bottle that provides a month's supply.
Metagenics features SPM Active One Daily, which is formulated to address the root causes of body soreness, particularly in muscles and joints. It is said to work by actively resolving the inflammation that contributes to discomfort and stiffness.
SPM Active One Daily may also support muscle, bone, and joint health by promoting your body's natural ability to reduce soreness and improve mobility, making it a helpful option if you are dealing with minor aches related to aging, physical activity, or everyday wear and tear.
The makers state that SPM Active features specialized pro-resolving mediators (SPMs), which are bioactive compounds derived from omega-3 fatty acids. These mediators play a crucial role in reducing inflammation naturally within the body.
Metagenics claims to source ingredients at pharmaceutical-grade standards, meaning each one meets high purity and potency levels. Instead of relying only on supplier information, Metagenics highlights re-testing every ingredient in-house, so you're less likely to be exposed to contaminants or underdosed formulas. As per the official website, each year, Metagenics does over 48,000 quality control tests on its raw materials and finished products. These tests check for heavy metals, microbes, allergens like gluten, and verify that each ingredient matches what's listed on the label. Through the TruQuality™ platform, Metagenics also helps you look up lab results for the exact batch you're using. This gives you direct access to safety and potency data, so you don't have to rely on vague claims or marketing.
As per the official website, Metagenics holds B Corporation certification across multiple regions, including North America, Europe, and Asia, a recognition that involves rigorous third-party evaluation of environmental impact, ethical sourcing, social responsibility, and governance practices. Their global certification was completed between 2019 and 2022, with an overall B Impact Score of around 81, significantly higher than the median benchmark of 51, indicating strong performance in areas like environmental stewardship and community engagement. Their commitment to sustainability is reflected in practical decisions, such as operating out of a LEED-certified headquarters in Aliso Viejo, California, which conserves energy and water. They also choose to package some of their products in glass bottles instead of plastic to reduce environmental waste.
Metagenics doesn't follow a one-size-fits-all approach, instead, it emphasizes personalized nutrition guided by licensed healthcare practitioners. This model allows you to receive targeted supplement plans based on your unique fitness profile, including lifestyle, genetics, and lab markers. Practitioners use clinical tools and protocols from Metagenics to recommend specific products. The brand supports this approach with science-backed, condition-specific products like UltraInflamX Plus for inflammation and Ultra Glucose Control for blood sugar support. These formulations are designed to address root causes rather than just symptoms. With options like ongoing subscriptions and practitioner check-ins, your plan stays consistent yet flexible, adapting as your fitness needs evolve. This gives you a more precise, effective way to support long-term wellness.
Metagenics consistently prices its supplements at the higher end of the market, often surpassing both Pure Encapsulations and Now Foods in cost per serving. For example, a 60-count bottle of Metagenics' PhytoMulti multivitamin is priced at $41.50, translating to approximately $0.69 per capsule. On the other hand, a comparable product from NOW Foods costs around $22.39–$27.99 for 60 capsules, or roughly $0.37–$0.47 per unit.
Pure Encapsulations, another premium-tier brand, offers its ONE multivitamin at a similar dosage for about $0.61–$0.72 per capsule. This pattern repeats across categories, with Metagenics' Vitamin D3 + K (60 softgels at $31.50) costing around $0.52 per unit, nearly six times more than Now Foods' Vitamin D3 10,000 IU (240 softgels at $19.99, or $0.08 per unit), and significantly higher than Pure Encapsulations' offerings at roughly $0.33–$0.44 per capsule.
While Metagenics justifies its higher pricing through quality standards and professional-grade positioning, its cost structure can be a barrier for you if you are looking for long-term wellness options without a premium price tag.
Metagenics has received multiple complaints on the BBB platform that highlight serious customer experience issues, particularly around billing, refunds, customer support, and order fulfillment. Users frequently report unauthorized subscription charges, delayed or partial refunds, and difficulties canceling orders, often requiring repeated follow-ups with little response. Several complaints mention long hold times, unreturned calls, and representatives who fail to follow through. Others describe website glitches, such as incorrect shipping charges, failed promotional discounts, or account restrictions triggered by foreign IPs and international credit cards, even when purchases were for personal use. These recurring problems point to weak infrastructure in subscription management, overly rigid fraud detection systems, and under-resourced customer service operations. These issues can create frustration, financial inconvenience, and a lack of trust in the brand. If you're ordering for the first time or managing recurring purchases, there's a risk of unexpected charges, poor communication, or delays in resolving mistakes. International buyers, in particular, may face unfair order cancellations or be wrongly flagged as resellers. Even if Metagenics eventually resolves the issue, the time and effort required can be exhausting and discouraging. For a brand that positions itself as premium and professional, this disconnect between promised quality and actual service delivery becomes a clear limitation, and could make you reconsider using or recommending their products.
Now Foods positions itself as an accessible wellness brand offering a broad product variety at an affordable price point. The brand's catalog features more than 1,400 items, spanning categories like dietary supplements, essential oils, natural foods, sports nutrition, and personal care.
As per its official website, Now Foods' product line includes options like Vitamin D3 5000 IU softgels, Pea Protein Powder, Lavender Essential Oil, and XyliWhite™ Toothpaste. To accommodate a range of lifestyle needs, Now Foods offers an impressive lineup of certified products, many of which are USDA Organic, Non-GMO Project Verified, Vegan, Kosher, Halal, and cruelty-free, making them suitable for ethically and diet-conscious users.
Now Foods states that its products are widely available on major online platforms like Amazon, iHerb, and Vitacost, as well as in physical retail stores and the company's website. This open-access model means that you don't need to go through a healthcare provider to obtain quality supplements. The brand also offers a 30-day return policy for purchases made through its official website.
Metagenics, on the other hand, is structured around clinical application and practitioner involvement. The brand offers a more specialized portfolio of approximately 200 to 300 products, many of which are patented. The focus is not on variety, but rather on condition-specific, research-supported formulations.
As per its official website, Metagenics features products that are commonly recommended in functional and integrative medicine settings, such as OmegaGenics® EPA-DHA 720, Estrovera®, and Insinase®, targeting concerns such as metabolic dysfunction, inflammation, hormonal imbalance, and cognitive decline. These supplements are often part of structured health protocols overseen by practitioners trained in clinical nutrition.
Now Foods focuses on everyday wellness, affordable, diverse, and easy-to-access supplements, while Metagenics caters to people addressing specific fitness challenges under medical supervision.
Meatgenics and Pure Encapsulations are both supplement brands, but they differ significantly in their formulation philosophies, pricing strategies, clinical tools, and user experiences.
Pure Encapsulations is known for its hypoallergenic, minimalist approach, producing clean-label supplements that are free from unnecessary additives, artificial colors, and many common allergens.
The brand claims that its products avoid ingredients like gluten, dairy, soy, magnesium stearate, and artificial coatings.
On the other hand, Metagenics emphasizes clinically studied, multi-ingredient blends designed to address broader wellness concerns.
While many Metagenics products are gluten-free and non-GMO, some formulas contain natural flavors, coatings, or additional excipients, especially in their lifestyle-focused lines like HerWellness™.
Refund policies show another point of divergence. Pure Encapsulations, when purchased through authorized resellers or healthcare practitioners, typically allows a 30-day return window, even if you're unsatisfied, as long as the product is unopened or in resalable condition. This offers moderate flexibility, especially for first-time users who may change their minds.
Metagenics, on the other hand, enforces a stricter 60-day satisfaction guarantee that only applies to products purchased directly from the official site or authorized sellers. While this longer timeframe may seem more generous, opened or used products are not eligible for a refund unless they are defective, and the policy excludes purchases from unauthorized third-party sellers entirely. The refund is also limited to the original end-user, making it less accommodating if you received the product as a gift or bought it secondhand.
Both companies offer extensive product catalogs, with Pure Encapsulations listing over 400 practitioner-only SKUs focused on single nutrients, clinical protocols, and detoxification blends. Key offerings include Magnesium Glycinate, Berberine UltraSorb™, NAC (600 mg), DIM Detox, and the O.N.E.™ Multivitamin series.
Metagenics also carries 450+ SKUs but with a broader emphasis on complex formulations that include medical foods, hormonal support, gut-brain axis blends, and lifestyle-specific collections. Notable lines include UltraFlora® Balance Probiotic, SPM Active® for inflammatory response, OmegaGenics® Fish Oil EPA-DHA 1000 mg, and the HerWellness™ suite of hormone-targeted products like Estrovera® and Rapid Period Relief.
As per its official website, Pure Encapsulations excels in practitioner-facing digital tools and clinical platforms. Their PureInsight™ system builds on the earlier PureGenomics® platform and includes optional DNA data integration, validated questionnaires like the GAD-7 for anxiety and PHQ-9 for depression, and symptom-specific assessments to generate personalized protocols. Meanwhile, Metagenics offers consumer-friendly tools like the HerWellness™ quiz, which helps women identify supplements suited to their hormonal life stage, and a category-based product filter. However, it lacks the level of clinical depth and diagnostic utility found in Pure's PureInsight platform.
Pure Encapsulations supports practitioners through its Pure Patient Direct virtual dispensary, which enables providers to prescribe and manage over 400 products without keeping in-office inventory. This service is free to practitioners and is designed to streamline supplement access for patients. Metagenics has a similar practitioner portal, offering access to user ordering, practice marketing support, and detailed fitness protocols, but emphasizes patient engagement through its brand-driven product experience and educational content.
Pure Encapsulations emphasizes supply chain transparency and reduced environmental impact, while Metagenics is a certified B Corp and also focuses on eco-conscious packaging and responsible sourcing across its product range.
To evaluate Metagenics, we looked at several key indicators of brand credibility, such as its age and history, customer review platforms like Trustpilot, and its rating with the Better Business Bureau (BBB).
Metagenics has been operating since 1983, which gives it over four decades of experience in the supplement industry. This long-standing presence reflects a level of stability and scientific depth, especially given its focus on practitioner-guided nutrition rather than mass-market appeal.
However, consumer-facing feedback reveals some limitations. On Trustpilot, Metagenics holds a low rating of 2.2 stars, based on a small sample of just over 10 reviews. While the review count is limited, the negative trend still raises concerns, especially for a brand positioned as a premium option. Complaints often mention poor customer service, shipping issues, and dissatisfaction with product effectiveness. Similarly, Metagenics holds a B rating on the BBB, which indicates there have been some customer complaints or unresolved issues.
While Metagenics shows strength in its clinical approach and longevity, the public-facing data points suggest room for improvement in customer experience and direct service.
One key factor we considered in evaluating Metagenics is its 60-day satisfaction guarantee, which reflects a solid level of brand accountability. The policy offers a reasonable timeframe for you to assess whether a supplement meets your expectations, which is important given that results with nutritional products often take several weeks to gauge.
However, the guarantee has clear boundaries. It only applies to purchases made directly from Metagenics or through authorized sellers. This means if you order from an unauthorized third-party source, even unknowingly, you won't be eligible for a refund or replacement. The policy also limits eligibility to the original end-user, excluding cases where the product was resold or gifted. These restrictions suggest the brand prioritizes controlled distribution and product integrity, but it also places more responsibility on you to verify your purchase source.
Metagenics is known for its focus on root-cause approaches to fitness through supplements and science-backed formulations. Its product development emphasizes pharmaceutical-grade standards, extensive quality testing, and targeted support for specific fitness concerns such as immune and metabolic health.
The brand also highlights its ethical and environmental commitments through B Corp certification and transparency tools like TruQuality™, which allow access to batch-specific testing data.
However, Metagenics is not without limitations. Its higher price point may be a barrier for long-term use, especially when compared to similar brands. The practitioner-only model can reduce accessibility, and repeated consumer complaints related to billing, returns, and customer service raise concerns about the reliability of support systems.
If you're considering Metagenics, working with a doctor is essential to ensure appropriate use, particularly given the potency and specificity of many of its products.
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