With age, your body's NAD+ (nicotinamide adenine dinucleotide) levels decline, which may lead to fatigue, increased oxidative stress, and a decline in physiological function. This is where nicotinamide riboside (NR) supplements could provide additional support by boosting NAD+ levels, they may help enhance mitochondrial function and improve endurance.
Nicotinamide riboside (NR) supplements have a specialized form of vitamin B3, which could help replenish diminished NAD+ stores and support cellular energy production. They may also help delay premature aging and support cognitive health.
In this blog post, we mentioned a list of the 10 best NR supplements available in 2025 after evaluating them on factors like potency, formulation, dosage, quality, safety standards, etc.
Genuine Purity's NR supplement may help support cellular regeneration, delay signs of premature aging, and aid in DNA maintenance. The supplement offers 300 mg of nicotinamide riboside per 2-capsule serving, contributing to healthy NAD+ levels.
Genuine Purity's NR may increase NAD+ levels, which may positively influence processes like gene expression, circadian rhythm regulation, and autophagy (the body's cellular cleanup process).
As per the makers, the Genuine Purity NR supplement uses liposomal encapsulation. The advanced delivery system protects the NR from stomach acid, enhances its solubility, and ensures better absorption into the bloodstream, maximizing the effectiveness of each dose.
Genuine Purity NR supplement is available in 1, 3, or 6-bottle packages, with added savings on bulk orders. It also comes with free shipping across the continental U.S. and a 97-day money-back guarantee.
NR Powder by Renue By Science features a 1,000 mg dose of nicotinamide riboside (NR) per serving (2 scoops) in a citrus-flavored blend. The powdered form may offer a flexible way to integrate NR into your daily routine by mixing it into water or any beverage.
Renue By Science's NR Powder may stimulate NAD⁺ (nicotinamide adenine dinucleotide) synthesis, which could help regulate redox reactions and energy metabolism in the body. The NR powder may also activate enzymes like sirtuins and PARPs, which may assist bodily processes like DNA repair, metabolism, and mitochondrial function.
The makers state that Renue By Science prioritizes transparency and quality. Every batch of NR powder undergoes rigorous testing in ISO-certified, cGMP-compliant laboratories to ensure purity and potency.
Probase Nutrition's NR supplement could help elevate energy levels and support brain health. It provides 500 mg of nicotinamide riboside hydrogen malate per capsule, which may help replenish your body's diminishing NAD+ levels.
As NAD+ levels naturally decline with age, Probase Nutrition's NR might help counter the dip by supporting the body's mitochondrial efficiency. Such effects could help your body generate energy more efficiently, which might contribute to improved focus, endurance, and alertness.
ProHealth Longevity's Nicotinamide Riboside Pro contains 500 mg of NIAGEN® and 250 mg of TMG (Trimethylglycine) per serving. The product could help support cellular health, cognitive function, cardiovascular performance, and metabolism.
Nicotinamide riboside in ProHealth Longevity supplement could support cognitive health by raising brain NAD⁺ levels, which may help lower neuroinflammation, boost processing speed, and improve cognitive performance.
ProHealth Longevity's Nicotinamide Riboside Pro may support heart health by improving blood pressure and reducing aortic stiffness. The added trimethylglycine may offer methylation support, improving your body's ability to process NR efficiently.
Mito-NR by Designs for Health provides 300 mg of nicotinamide riboside chloride (NR), 200 mg of Coenzyme Q10, and 50 mg of trans-geranylgeraniol per serving (2 capsules). NR is a variant of vitamin B3 linked to the production of NAD⁺, which may support metabolic activity and DNA synthesis.
Coenzyme Q10 in Mito-NR may support the mitochondrial electron transport chain, a process that might support nutrients to cellular energy ATP conversion. Trans-geranylgeraniol (GG) might contribute to maintaining healthy cellular function and support the body's natural CoQ10 production.
Designs for Health Mito-NR are available in a 60-capsule bottle (30 servings). It is also free from common allergens, such as soy, GMOs, dairy, and gluten.
As per its official site, Thorne's ResveraCel delivers 415 mg of nicotinamide riboside (NR) per 2-capsule serving. It also features trans-resveratrol, quercetin phytosome, and betaine anhydrous. These ingredients could help support NAD⁺ activity, mitochondrial function, and cellular aging processes.
The inclusion of resveratrol in ResveraCel may help activate sirtuins, enzymes linked to cellular longevity. Quercetin phytosome could support the clearance of senescent (aging) cells and enhance the duration of resveratrol activity in the body. Betaine may help maintain DNA integrity and aid in neurotransmitter balance.
As per the makers, Thorne's ResveraCel could also support a healthy metabolism, insulin sensitivity, fat processing, and mitochondrial structure.
Pure Encapsulations' NR Longevity may support healthy aging by promoting cellular energy production and reducing oxidative stress. The makers state that the formula is free from unnecessary additives like preservatives, fillers, and trans fats.
Nicotinamide riboside in NR Longevity may boost NAD+ levels, which is a coenzyme essential for mitochondrial function, energy metabolism, and DNA repair. NR Longevity also features resveratrol and sulforaphane, both of which contribute to healthy aging support.
Resveratrol could optimize mitochondrial function, while sulforaphane activates the Nrf2 pathway, improving your body's natural antioxidant defenses. The makers suggest taking two NR Longevity capsules 1-2 times daily, with or between meals.
GeneX Formulas' NR provides 300 mg of nicotinamide riboside chloride per 2-capsule serving, which may contribute to longevity and vitality. The supplement could also help support the immune function, cardiovascular health, and muscle performance.
The makers state that GeneX NR may aid the function of longevity genes, which might help delay the cellular decline often associated with aging. GeneX Formulas NR is made in the USA in NSF and GMP-certified facilities, indicating adherence to strict quality control and manufacturing standards.
CogniTune NR+ supplement may help support healthy aging, cellular vitality, and energy production. It features ingredients like resveratrol, vitamin C, grape seed extract, and pine bark extract, which may decrease oxidative stress and support long-term cellular health.
The CogniTune NR+ supplement also includes BioPerine, which may further enhance the absorption of the active ingredients. CogniTune NR+ comes with a 60-day money-back guarantee, which may indicate the maker's faith in its formulation.
Burminy claims that its Liposomal Nicotinamide Riboside supplement could minimize age-related decline in NAD+ levels. The supplement provides 500 mg of nicotinamide riboside, 150 mg of trans-resveratrol, and 250 mg of quercetin phytosome per serving (2 capsules).
The liposomal delivery system of Burminy NR supplement may enhance the bioavailability of its active ingredients, ensuring efficient absorption. The inclusion of resveratrol and quercetin might help tackle age-related fatigue and boost focus.
NR supplements may cause indigestion post-consumption, especially supplements with high NR doses or liposomal delivery. These NR versions may increase the rate at which NR enters your bloodstream, making your stomach process a concentrated load of active compounds.
NR supplements with added ingredients like resveratrol, quercetin, or grape seed extract may cause even more digestive discomfort. They may stimulate digestive enzymes and ramp up your stomach acid, often leaving you bloated, gassy, or with a churning gut.
Even though many NR supplements are often marketed as “flush-free,” you might still experience warmth and redness in your face, neck, or chest, especially with supplements that contain 500 mg NR or more per dose. Your body converts NR into nicotinamide and ultimately into nicotinic acid, which may trigger vasodilation. If your NR supplement also includes resveratrol or BioPerine, the flushing can intensify due to boosted blood flow and enhanced absorption.
NR supplements have the potential to raise liver enzyme levels. Some NR supplements pair NR with TMG to support methylation, but the combination may overstimulate detox functions and overburden the liver, particularly if you have preexisting liver sensitivity.
Many NR supplements also include compounds like resveratrol, quercetin, and sulforaphane, which activate antioxidant and detoxification pathways through Nrf2. These ingredients may push your liver into overdrive when paired with NR supplements, triggering elevations in ALT and AST enzymes.
Some NR supplements include fat-soluble compounds like CoQ10 and geranylgeraniol, both of which demand significant liver processing. This may further strain your hepatic function, potentially triggering side effects like jaundice, appetite loss, dark urine, etc.
For evaluating the best NR supplements in 2025, we examined each brand's reputation using Trustpilot and BBB ratings. Genuine Purity has a 4.4 Trustpilot score based on 30+ reviews, though it lacks a BBB rating. Renue by Science followed with a 4.0 Trustpilot rating from over 35+ reviews, although its C rating on BBB and five complaints, with failure to respond to one complaint, lowered its score.
Probase Nutrition earned third place due to a 3.8 Trustpilot score despite limited visibility and no BBB rating.
ProHealth Longevity holds an A+ rating on BBB, followed by Designs for Health, with a similar A+ BBB rating. However, both brands remain unrated on Trustpilot.
Despite its popularity and premium supplements, Thorne has a C+ BBB rating and no Trustpilot presence. Pure Encapsulations holds an A- BBB rating and received six complaints, with no public review data available on Trustpilot.
Brands like Genex Formulas, CogniTune, and Burminy have no verified ratings on either Trustpilot or the BBB. Without public feedback or third-party accountability, these brands ranked lowest in terms of brand trustworthiness.
When evaluating the best NR supplements in 2025, we focused on balancing price with the overall value each product provides. Burminy's Liposomal Nicotinamide Riboside provides the best value, offering 100 capsules for $24.98. The inclusion of liposomal delivery may also enhance NR absorption.
Similarly, CogniTune NR + Resveratrol costs $39.97 for 60 capsules, which combines NR with resveratrol, delivering a comprehensive formula at a competitive price. Thorne ResveraCel, priced at $58 for 60 capsules, offers an NR supplement with added ingredients like quercetin and betaine.
Pure Encapsulations NR Longevity costs $59.90 for a bottle with 60 capsules, delivering decent value with premium formulation. Similarly, ProHealth Longevity's NR Pro provides a bottle (60 capsules) for $64.95.
Probase Nutrition's NR Supplement costs $24.99 for a bottle with 30 capsules, offering a budget-friendly option. However, it provides only 30 servings per bottle, which slightly reduces its value compared to other NR supplements.
Genuine Purity's NR costs $59 for 60 capsules but lacks additional ingredients to make it stand out among competitors. Renue by Science's NR Powder provides one bottle (60 servings) for $79, offering value for people who prefer a powdered form of NR supplements.
Designs for Health Mito-NR is priced at $82.75 for 60 capsules, which has a premium pricing that is out of reach for the average user. Genex Formulas NR is the least cost-effective supplement, as it provides one bottle (60 capsules) for $119.61.
In evaluating the best NR supplements in 2025, we considered the refund policy provided by each brand to ensure customer flexibility and trust in the purchase process. ProHealth Longevity offers a 100-day satisfaction guarantee, allowing returns of unused portions for a full refund or credit, excluding shipping charges.
Genuine Purity follows closely by providing a 97-day money-back guarantee that includes returns of empty bottles with no questions asked. Renue by Science provides a 60-day refund window, handling return requests through its support team. CogniTune also allows refunds or replacements within 60 days of purchase without requiring any explanation for returns within this period.
Thorne backs its supplements with a 60-day refund window but requires contacting customer service if a resolution with the original seller is not possible. Designs for Health has a 30-day refund policy, only accepting returns on unopened items, and excludes heat-sensitive products.
Genex Formulas also provides a 30-day return policy but does not provide reimbursement for return shipping charges. Pure Encapsulations allows returns within 30 days of purchase for unopened, unused products in original packaging, with preauthorization and a 15% processing fee.
Probase Nutrition has the shortest refund window, accepting returns only on unopened products within 14 days of purchase, and requires a special return label. Burminy does not provide any public information on its return policy, which may raise concerns about customer safety.
NR (nicotinamide riboside) supplements may support healthy aging and cellular function by boosting NAD⁺ levels, which naturally decline with age. These supplements could enhance mitochondrial performance, energy metabolism, and cellular health. Research suggests that increasing NAD⁺ levels may activate longevity-related pathways in the body.
The NR supplements discussed in this article offer a range of options, from high-dose versions to antioxidant-enriched blends, each designed to support metabolic health and aging. However, the effectiveness of NR supplements might vary depending on factors like health status, dosage, and duration of use.
NR supplements may also trigger digestive discomfort, such as bloating, gas, and indigestion. They might also cause flushing, raise liver enzyme levels, dizziness, headaches, and an upset stomach.
While NR supplements offer potential benefits for longevity and cellular health, it is important to approach them with realistic expectations. Although short-term studies show promising results, the full impact of NR supplementation over extended periods is not yet fully understood.
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