Home » 7 Best NAD+ (NMN) Supplements In 2024

7 Best NAD+ (NMN) Supplements In 2024

As you age, NAD+ levels tend to decline, contributing to various health challenges. NMN is a natural compound that could help boost your body's NAD+ production, supporting essential functions like DNA repair, immune health, and metabolism.

As more people look to optimize their health and longevity, NMN supplements have become increasingly popular. The rise in interest also highlights NMN's potential to support vital cellular functions and promote long-term well-being.

Choosing the right NMN supplement from the wide variety available can feel overwhelming. To simplify the process, we've reviewed and ranked the top 7 NMN supplements, evaluating their benefits, potential side effects, dosages, and other important factors.

In this guide, we'll explore the advantages and risks of incorporating NMN into your daily routine and provide a selection of the best options to help support your health goals.

Benefits of NMN supplements

  • NMN is a precursor to NAD+, which claims to play a crucial role in generating cellular energy, potentially supporting your overall metabolic health.
  • By increasing NAD+ availability, NMN may boost cellular energy, leading to improved muscle function and better physical performance.
  • Studies suggest NMN may promote healthier metabolic function, assisting with weight management and supporting insulin sensitivity.
  • NMN has shown a potential to enhance memory retention and cognitive function. Preliminary research indicates that it might protect against age-related cognitive decline, supporting neurological health.
  • NMN may support endothelial function, which contributes to better heart health and vascular function.
  • NMN has demonstrated anti-inflammatory properties that might help reduce chronic inflammation, a common issue associated with aging.

7 Best NAD+ (NMN) Supplements

  1. partiQlar Pure NMN

    PartiQlar Pure NMN claims it might boost your energy levels, improve your thinking, and support your metabolic health. The official site says it follows FDA-registered and GMP-certified manufacturing practices so that you can feel confident about its quality.

    The makers say NMN might support essential cellular processes by increasing NAD+ availability, which may help with DNA repair and could improve your insulin sensitivity.

    PartiQlar Pure NMN claims it might enhance your energy by increasing NAD+ (Nicotinamide Adenine Dinucleotide), which is essential for mitochondrial function and optimal energy production in your cells.

    This could make you feel more energetic and active throughout the day. It claims to boost your endurance and strength, helping you perform better during physical activities and aiding in muscle recovery. It might also support DNA repair, which is crucial for maintaining cellular health as you age and could prevent age-related decline.

    NMN may improve your insulin sensitivity, which is vital for managing blood sugar levels, and might decrease the chances of type 2 diabetes.

    It could promote brain health by reducing oxidative stress and inflammation, potentially improving your cognitive function and memory, and might protect against neurodegenerative diseases.
    partiQlar Pure NMN

    Key Ingredients of partiQlar Pure NMN

    Nicotinamide mononucleotide

    NMN might help boost energy production in your cells. It could improve how your mitochondria, the energy factories of your cells, work. This may support your metabolic health. You might find it improves your muscle function and endurance, which could be helpful if you're an active individual looking to boost your physical abilities. It also claims to support healthy aging by activating sirtuin proteins, which may boost longevity.

    Pros & Cons

    Pros

    • It claims to have 99% purity, which might help support your cognitive and metabolic health.
    • It claims users often feel more energetic
    • If you're not satisfied, you can get your money back within 60 days.
    • It may help improve your metabolism, supporting better energy use in your body.

    Cons

    • You can only buy it from the PartiQlar website, which might make it hard for some people to purchase.
    • Some users may have mild stomach problems after taking it
  2. Omre NMN + Resveratrol

    Omre NMN + Resveratrol claims to combine two powerful compounds that might work together to boost your health. It gives you nicotinamide mononucleotide (NMN) and resveratrol in capsule form, which could help increase your cellular energy and overall wellness. The combination of NMN and resveratrol might help raise NAD+ levels in your body, which are crucial for your metabolism and cellular repair. NMN is absorbed by your cells and turns into NAD+, which could help restore your cell functions and improve how your mitochondria work. Resveratrol is known as a natural antioxidant found in foods like red grapes and may enhance sirtuin activity, which might further support NAD+ production. Omre NMN + Resveratrol comes with a 30-day return window, which you might want to consider since other companies offer a return window of 60 days or more. The makers recommend you take Omre NMN + Resveratrol with foods rich in fat since resveratrol is fat-soluble. This could help ensure you absorb it better.  While the price might seem high, the formula's dual action could offer significant value, especially if you consider using it for an extended period.
    Omre NMN + Resveratrol

    Key Ingredients of Omre NMN + Resveratrol

    • Resveratrol

      Resveratrol could help lower blood pressure and improve cholesterol levels, potentially decreasing heart disease risk. It is a natural compound that is known for its critical antioxidant properties and helps protect cells from oxidative stress. Resveratrol might support heart health by improving blood vessel function and reducing inflammation. It may activate sirtuins proteins that help with enhanced longevity and metabolic health, promoting healthier aging. Resveratrol might enhance cognitive function and memory by aiding in decreasing neuroinflammation.

    • Nicotinamide mononucleotide

      NAD+ is said to be crucial for making energy, repairing DNA, and cell communication. It might help you produce more energy, improve your physical performance, and support a healthy brain function. By boosting NAD+ levels, NMN could support your overall health. Nicotinamide mononucleotide (NMN) might help your body produce nicotinamide adenine dinucleotide (NAD+). It is believed to support DNA repair mechanisms, which may mitigate the effects of aging and improve overall cellular resilience. It has also been linked to enhanced insulin sensitivity and cognitive health.

    • Bioperine

      Bioperine, a special extract from black pepper, claims to boost how well your body absorbs various nutrients and supplements. This natural compound has piperine, which may enhance how vitamins and minerals get absorbed. When you combine it with NMN, Bioperine claims to help ensure your body absorbs and uses nutrients optimally. Bioperine in NMN supplements might improve absorption rates, resulting in more effective cellular uptake. It may enhance the health benefits related to NAD+ production, supporting your energy metabolism and overall vitality. Research shows that Bioperine could help increase the bioavailability of compounds by up to 30%.

    Pros & Cons

    Pros

    • It may support healthy cellular energy production and metabolism.
    • It may enhance memory and cognitive function.
    • It is claimed to have the potential to aid in weight management and insulin sensitivity.

    Cons

    • The combination of NMN and resveratrol often results in a higher price point compared to similar products.
    • Responses can differ widely among individuals
  3. ProHealth NMN Pro™ Powder

    ProHealth NMN Pro™ Powder could be a suitable option if you're looking to raise your NAD+ levels and support healthy aging. It may help boost your energy at the cellular level and support longevity.

    ProHealth NMN Pro™ Powder may help you adjust the dosage because it's in powder form. This flexibility could be useful if you want to start with minimal amounts and gradually increase.

    Since NMN helps make NAD+, which may support energy production and DNA repair, it may have positive effects on your cells. NMN Pro Powder could skip the digestion process in your stomach and get into your bloodstream faster. The makers claim this might increase how much of the product your body can use. Such effects may help NMN Pro Powder to be absorbed directly into your blood vessels in the mouth and under your tongue. However, with a price of about $ 123 for 100 grams, some people might find it a bit expensive for their daily use. ProHealth also offers a 100-day money-back guarantee, which might give you confidence in trying it out where you can also have more than a 3-month guarantee from the makers to return the product if you do not notice any changes.
    ProHealth NMN Pro™ Powder

    Key Ingredients of ProHealth NMN Pro™ Powder

    Uthever® β-Nicotinamide Mononucleotide

    Uthever® β-Nicotinamide Mononucleotide (β-NMN) may support optimal absorption in the body. It could promote DNA repair and help cells stay strong, possibly reducing age-related decline. Additionally, it is said to be connected to better insulin sensitivity and energy metabolism, which may enhance overall well-being. Uthever® NMN  could also help maximize bioavailability, ensuring that the active ingredient is efficiently absorbed and utilized by the body.

    Pros & Cons

    Pros

    • It claims to contain natural formula without additives or fillers.
    • It comes in a powder form which may add to its convenience
    • It is said to be third-party tested, which may indicate its purity and effectiveness.

    Cons

    • Some people might find the taste unpalatable.
    • ProHealth NMN Pro™ Powder may be priced higher than other NMN options on the market.
  4. Lifeforce Peak NMN

    Lifeforce Peak NMN claims to support cellular health and longevity. The makers state that NMN could produce NAD+ (nicotinamide adenine dinucleotide), which is important for energy production, DNA repair, and cell renewal. Lifeforce Peak NMN aims to boost declining NAD+ levels, which may boost healthy aging. The makers also highlight that Lifeforce Peak NMN is pure and of high quality. Independent labs have tested it to make sure it works well and contains no synthetic fillers or artificial preservatives. Lifeforce Peak NMN may also support neuroprotective pathways for long-term brain function and aid in DNA repair, which could promote cellular health and longevity. The makers also claim that NMN supports brain health, helping you think clearly with enhanced focus.
    Lifeforce Peak NMN

    Key Ingredients of Lifeforce Peak NMN

    • White Mulberry Extract

      White Mulberry Extract comes from the leaves of the Morus alba tree. It is rich in compounds like 1-deoxynojirimycin (DNJ), which may help block enzymes that digest carbohydrates. Research shows that White Mulberry Extract might improve blood sugar levels and insulin sensitivity. It contains active compounds like flavonoids, alkaloids, and vitamins that may act as antioxidants. Studies suggest that this extract could lower blood sugar after meals, which may help with metabolism. It might also aid in weight management by increasing metabolic rate and helping with weight loss. White Mulberry Extract may reduce oxidative stress, promoting overall health, and it might improve cholesterol levels for better heart health.

    • Berberine HCl

      Berberine HCl is a strong natural compound that may help manage glucose levels and improve how well your body responds to insulin. It could lower total cholesterol and triglyceride levels, which might be good for your heart health. Berberine also has anti-inflammatory properties, which may help reduce inflammation in the body. It might activate an enzyme called AMP-activated protein kinase (AMPK), which may play an important role in keeping cellular energy balanced.

    Pros & Cons

    Pros

    • It may help manage blood sugar levels, providing stable energy.
    • Consumers may save 20% with a monthly subscription.
    • It may support brain function, healthy aging, and metabolic health.

    Cons

    • It might be more expensive than other NMN supplements, which may not fit all budgets.
    • Users typically need to take three capsules, which could be inconvenient for some.
    • Some users could experience mild stomach issues.
  5. Doublewood NMNH Supplement

    Doublewood's NMNH (Dihydronicotinamide Mononucleotide) supplement claims to enhance NAD+ levels for improved energy and healthy aging. It is claimed to be non-GMO, vegan, and gluten-free. Doublewood NMNH is said to be free from synthetic fillers or unnecessary additives. Each Doublewood NMNH bottle contains 60 capsules, providing a convenient 30-day supply when taken as directed, making it easy to add to daily routines. Doublewood's NMNH is backed by a 30-day money-back guarantee, allowing you a month to evaluate its effects on your health.
    Doublewood NMNH Supplement

    Key Ingredients of Doublewood NMNH Supplement

    NMNH (Dihydronicotinamide Mononucleotide)

    NMNH is thought to help convert nicotinamide into NAD+, which may provide a quicker source of energy for cells. It might boost the body's ability to repair DNA, promoting healthier cells and longer life. Research suggests that NMNH could improve metabolic functions, which may help with weight management and insulin sensitivity, both important for overall health. Early studies indicate that NMNH might support brain health by improving how brain cells function and helping with memory retention through better energy availability.

    Pros & Cons

    Pros

    • It is a non-GMO product manufactured in the USA from globally sourced ingredients.
    • Safe for people adhering to a vegan lifestyle.
    • It claims to undergo rigorous third-party testing for quality assurance.

    Cons

    • Taking two capsules daily may feel like too much for some people.
    • Users might have to wait longer to see noticeable effects.
  6. GenuinePurity Liposomal NMN

    As per the official website, Genuine Purity Liposomal NMN uses liposomal encapsulation, which may help NMN pass through the digestive system more easily and reach the bloodstream. This process may support cellular repair and energy production. Each serving contains 250 mg of NMN, which may offer favorable benefits for healthy aging and longevity. It is said to be made from non-GMO ingredients and is free of synthetic additives, prioritizing user safety and well-being. Genuine Purity Liposomal NMN is available for $69 per bottle, with additional savings for bulk purchases. The makers also provide a 97-day money-back guarantee.
    GenuinePurity Liposomal NMN

    Key Ingredients of GenuinePurity Liposomal NMN

    Dihydronicotinamide Mononucleotide

    Dihydronicotinamide Mononucleotide (NMNH) compound helps in producing nicotinamide adenine dinucleotide (NAD+), an essential coenzyme in the body. NMNH may help increase NAD+ levels, which could support cellular energy production, DNA repair, and overall cellular health. It is thought to offer potential health benefits, such as promoting healthy aging, improving metabolic functions, and enhancing brain health.

    Pros & Cons

    Pros

    • It comes with a 250-gram clinically dosed serving.
    • It offers a 97-day money-back guarantee
    • It is said to be gluten-free, soy-free, dairy-free, and sugar-free.

    Cons

    • Its $69 price point could be considered higher for some people.
    • Mild gastrointestinal discomfort in some users
  7. Wonderfeel Youngr™ NMN

    Wonderfeel Youngr™ NMN claims to be a high-quality source of Nicotinamide Mononucleotide (NMN). This is critical for making NAD+, a coenzyme that helps with energy and metabolism in cells. Created by Dr. Andrew Salzman, it is said to focus on being vegan-friendly and is backed by science. Wonderfeel Youngr™ NMN also includes ingredients like ergothioneine, trans-resveratrol, olive fruit extract, and vitamin D3. As per the official website, each Wonderfeel Youngr™ NMN capsule has 450 mg of NMN, and the recommended daily dose is two capsules, totaling 900 mg. This amount is higher than what you usually find in other products, which is usually between 100 to 350 mg. However, the price may be higher, $88 for a one-time purchase or $73 if you subscribe.
    Wonderfeel Youngr™ NMN

    Key Ingredients of Wonderfeel Youngr™ NMN

    • Vitamin D

      Adequate Vitamin D levels may help prevent chronic diseases, as deficiency could be linked to conditions like osteoporosis, cardiovascular disease, and certain cancers. It may help in healthy immune function, muscle health, and regulating inflammation, which is essential for overall well-being. Optimal Vitamin D levels might also support metabolic health and enhance insulin sensitivity. Vitamin D, known as a fat-soluble vitamin, may support bone health and enhance calcium absorption in the gut.

    • Trans-Resveratrol

      Trans-resveratrol is known for its antioxidant properties, which help combat oxidative stress, a key factor in aging and chronic diseases. It may synergistically enhance the benefits of NMN supplementation by activating sirtuins proteins that regulate cellular health and longevity.

    • Olea25

      Olea25 from olive leaf plant extract may support the body's natural production of NAD+ and could help increase energy levels in cells. Its anti-inflammatory effects could also protect against long-term inflammatory health conditions. The antioxidant properties of oleuropein might help fight oxidative stress, which is said to be a major factor in aging and chronic diseases. Clinical studies suggest that Olea25 may regulate blood pressure and improve insulin sensitivity.

    Pros & Cons

    Pros

    • Made in facilities that follow strict quality controls in the U.S., ensuring high standards.
    • It may support mitochondrial health.
    • It may help boost energy levels and mental focus.

    Cons

    • Personal experiences could vary.
    • It could be considered expensive by some people.

What are NAD+ (NMN) Supplements?

NAD+ (NMN) supplements may help boost NAD+ levels in the body. NAD+ is an important part of all living cells, playing a role in energy production, DNA repair, and keeping cells healthy. NMN supplements are made from NMN compound that helps create NAD+, and they may support several functions in the body. They could improve energy metabolism, help with cellular repair, and may support healthy aging by restoring NAD+ levels.

Side effects of NMN supplements

While NMN is generally well-tolerated, some users may experience mild side effects, particularly at higher doses. The following are potential side effects of NMN supplementation:

  • Some people may experience headaches, which may be linked to changes in cellular metabolism.
  • Mild digestive discomfort, including diarrhea and nausea, can occur, particularly at higher dosages.
  • Feelings of fatigue or indigestion.

How to choose the best NAD+ (NMN) Supplements?

  1. Security

    Always choose NMN supplements that have been tested by independent labs, as this testing checks for purity, strength, and safety, giving you peace of mind that the product contains what it says without harmful substances. Brands that share where they get their ingredients show they care about quality and ethics, as knowing the source of the NMN can help ensure it meets high safety and effectiveness standards. The way NMN supplements are packaged can affect how well they work, so look for products in tamper-proof containers that protect against moisture and light.

  2. Convenience

    Convenience plays an important role in how easily someone can include NMN supplements in their daily routine, which may affect their commitment to using them regularly. There are different forms of NMN supplements available, such as capsules, powders, and sublingual tablets, so users can choose the suitable option that best fits their lifestyle.

    Capsules are popular because they are easy to take with water and don't need any extra preparation. Powder forms could be versatile and can be mixed into drinks or smoothies, appealing to those who like to customize their intake. Sublingual tablets, which dissolve under the tongue, could offer faster absorption, making them attractive to users who want quick effects.

    The timing of taking these supplements can also affect convenience. Some NMN supplement brands suggest taking them in the morning or evening, which helps users fit them into their daily routines. For busy individuals, single-dose packets or easy-to-use containers can simplify the process, making it easier to stick to a routine without the hassle of measuring out doses.

  3. Effectiveness

    To check how well an NMN (Nicotinamide Mononucleotide) supplement works, you can follow some simple steps. Look for scientific studies that back up the claims made by the NMN supplement. Good research can help you see if NMN really increases NAD+ levels and provides the health benefits promised. You should also try and check the amount of NMN in the supplement, as effective doses usually range from 250 mg to 900 mg per day.

    Reading reviews from other users could also give you an idea of their experiences, including any benefits or side effects they faced. It's also important to choose products that third-party labs have tested to ensure safety and that they contain the correct amount of NMN without harmful ingredients. Look for quality ingredients, like non-GMO and vegan options, to find a better product.

    If you try an NMN supplement, pay attention to any changes in your health, like your energy levels and mental clarity, and consider keeping a journal of your experiences. It's also a good idea to talk to a doctor before starting an NAD+ (NMN) supplement.

  4. Cost

    The price of NMN supplements can vary a lot based on several factors, including the brand's reputation, purity, and any extra ingredients.

    Well-known brands usually spend more on research and quality control, which may lead to higher prices. However, this could also mean that their products are more reliable, so it's a good idea to look into the brand's history and transparency.

    NMN Supplements with higher purity levels often cost more. Those that third-party labs have tested for quality assurance might also have a higher price, but they can provide you with confidence about their safety and effectiveness.

    NMN supplements are available in capsules, powders, or sublingual tablets, and the type of formulation can also affect the price. For example, enteric-coated capsules, which are made for better absorption, usually come at a higher cost.

  5. Dosage

    Finding a NAD+ (NMN) supplement with a suitable dosage is important for getting the most benefits while staying safe. Common dosages may range from 250 mg to 1000 mg per day, but individual needs could vary based on personal goals and health conditions. It's always a good idea to talk to your doctor before starting NMN supplementation. The timing of your intake could also influence its benefits. Some makers suggest taking NMN in the morning, which might help with energy levels throughout the day, while others recommend taking it in the evening for better recovery during sleep.

Frequently Asked Questions

  • Can NMN Supplements Interact With Medications or Other Supplements?
    NMN supplements may interact with some medications or other supplements, which could affect how well they work or their safety. It's a good idea to talk to a healthcare professional before mixing NMN with any prescribed treatments or dietary products.
  • Is NMN Safe for Long-Term Use?
    Long-term use of NMN is generally considered safe, with minimal side effects reported. However, ongoing research is necessary to understand its long-term effects fully, and consultation with a healthcare professional is recommended before prolonged use.
  • Are There Specific Dietary Restrictions While Taking NMN?
    There are no specific dietary restrictions while taking NMN, but having a balanced diet full of nutrients may help improve its effects. It's a good idea to talk to a healthcare provider for advice based on your health needs and goals.
  • How Does NMN Compare to Other Nad+ Precursors?
    NMN is a strong precursor to NAD+, which may effectively boost cellular NAD+ levels. Compared to other options like NR (Nicotinamide Riboside), NMN might have better bioavailability and could offer more benefits for aging, metabolic health, and energy production in cells. More research may be needed to explore these potential advantages.
  • What Age Group Is Most Likely to Benefit From NMN Supplementation?
    People aged 40 and older may benefit the most from NMN supplementation because NAD+ levels tend to decrease as we age. Taking NAD+ (NMN) could help improve energy metabolism, support brain function, and promote overall health as we get older.

Conclusion

When selecting the best NAD+ (NMN) supplements, it's important to consider effectiveness, safety, and convenience, as the right choice could significantly impact your health and vitality. Among the wide range of options available, the top seven supplements highlighted in this guide are recognized for their premium quality, independent testing, and positive consumer feedback. To maximize the benefits that NMN supplements may offer, think about adding simple lifestyle changes, like staying hydrated, engaging in physical activity, managing stress through mindfulness or relaxation techniques, and maintaining a balanced diet. These practices may enhance cellular health and energy levels, complementing the effects of NMN supplementation. Always consult with a doctor before starting any new NMN supplement to ensure it aligns with your health needs and goals.

Disclaimer
  • This review's general information is not intended to be taken as medical advice and should not be used as a replacement for speaking with a doctor.
  • Never rely on anything you read or accessed through this review without consulting a doctor, and never put off getting medical help.
  • Individual results may differ because they are subjective.
  • Before using any product, please speak with your doctor if you have any underlying health issues or are using any prescription medications.
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This project was supported in part by NSF Grant IIS-03-25867 (ITR: An Electronic Field Guide: Plant Exploration and Discovery in the 21st Century) and by the Washington Biologists' Field Club.
Any opinions, findings, conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the official views, opinions, or policy of the National Science Foundation (NSF).