Home » 8 Best Nitric Oxide Supplements in 2025

8 Best Nitric Oxide Supplements in 2025

Best Nitric Oxide Supplements

Your body produces nitric oxide, which has a key role in blood flow, oxygen delivery to muscles, and overall circulation. Factors like aging, poor diet, and inactivity can reduce NO levels, leading to fatigue, slower recovery, and reduced stamina. Taking a nitric oxide supplement may help you experience improved exercise performance, better cardiovascular function, increased energy, and enhanced muscle growth.

While your body naturally produces nitric oxide, supplementation can provide an extra boost. These supplements may also enhance stamina, muscle pumps, recovery speed, and heart health. These effects could be useful for athletes, bodybuilders, and fitness enthusiasts.

This article covers the 8 best nitric oxide supplements, highlighting their health benefits, potential side effects, and their role in supporting heart health. In the end, we have also provided some tips on choosing the best nitric oxide supplement based on your health goals and needs.

8 Best Nitric Oxide Supplements

  1. CrazyBulk Nitric-Max

    CrazyBulk Nitric-Max

    CrazyBulk Nitric-Max claims to enhance your workout potential by boosting your natural nitric oxide levels. It could help improve blood flow and oxygen circulation, giving you more energy, endurance, and muscle pumps during every workout.

    As per the official website, Nitric-Max works by relaxing and widening your blood vessels. This allows more oxygen, blood, and nutrients to reach your muscles, leading to better strength and stamina. It may also help delay fatigue so you can stay consistent with your routine, maximizing your workout results.

    The makers advised taking four Nitric-Max capsules with water about 20 minutes before your workout. You are recommended to follow this routine for two months to experience its benefits.

    Pros & Cons of CrazyBulk Nitric-Max

    Pros

    • It may boost energy and endurance, helping you push through tough workouts.
    • It could enhance muscle pumps by improving blood flow to muscles.
    • It may support faster recovery, helping you return to training quickly.
    • It might increase strength and stamina by delivering more nutrients to muscles.
    • It could be easy to use, with just four capsules before your workout.

    Cons

    • You could find it difficult to swallow.
    • It is only available on its official website.
    • Results could vary and you may take longer to experience any improvement.
  2. UMZU Redwood Nitric Oxide Supplement

    UMZU Redwood Nitric Oxide Supplement

    UMZU Redwood Nitric Oxide Supplement claims to support your heart health and boost your energy naturally. It may help your body make more nitric oxide, which could promote healthy blood pressure and keep your extremities warmer.

    UMZU Redwood Nitric Oxide Supplement includes garlic and vitamin C, which could help improve nitric oxide levels. Vitamin C in the formula may support vein health, while garlic might help keep your blood vessels healthy, promoting better blood flow throughout your body.

    The makers also added horse chestnut extract, which could help improve circulation and support healthy veins. This may help reduce tiredness and fatigue by making sure your body receives all the nutrients and oxygen it needs. As per the official website, UMZU Redwood is made in a cGMP-certified facility, ensuring it adheres to strict quality control standards.

    Pros & Cons of UMZU Redwood Nitric Oxide Supplement

    Pros

    • It may help promote healthy blood pressure and circulation.
    • It could help increase nitric oxide production for a natural energy boost.
    • It might help enhance blood flow and nutrient delivery.
    • It could also support healthy veins and blood vessels.
    • It may help you overcome tiredness and feel more energized.
    • cGMP certified, lab-tested, and assembled in the USA for safety.

    Cons

    • Allergic reactions could occur.
    • It may not provide the instant energy effect like stimulant-based supplements.
    • It's natural ingredients could interact with blood pressure or anticoagulant medications.
  3. Xtendlife VasQFlow Nitric Oxide Supplement

    Xtendlife VasQFlow Nitric Oxide Supplement

    According to the official website, Xtendlife VasQFlow may help improve circulation, blood pressure, and exercise performance. It is said to contain red spinach, black garlic, and other ingredients that could help boost nitric oxide levels, helping deliver oxygen and nutrients to your cells and organs.

    Red spinach extract in VasQFlow from Xtendlife might provide more nitrates than beetroot powder, which your body could turn into nitric oxide to support healthy blood flow. The special extraction process ensures harmful substances are removed, which might make it more effective.

    The makers state that VasQFlow also includes quercetin, which may help maintain healthy blood pressure, and black garlic and grape seed extracts, which might act as antioxidants to support circulation and prevent blood vessel narrowing. Xtendlife VasQFlow claims to help reduce muscle soreness and improve exercise performance, making it suitable for boosting circulation and aiding recovery.

    Pros & Cons of Xtendlife VasQFlow Nitric Oxide Supplement

    Pros

    • It could help improve circulation and warm and cold hands and feet.
    • It may reduce muscle soreness and speed up recovery.
    • The bioavailable formula could enhance nutrient absorption.
    • Red spinach extract may provide a stronger nitrate source.

    Cons

    • It could cause stomach discomfort, especially on an empty stomach.
    • Long-term use might be needed to see noticeable results.
    • It is only accessible through its official website.
  4. Nutricost Nitric Oxide Booster

    Nutricost Nitric Oxide Booster

    Nutricost Nitric Oxide Booster promises to help increase blood flow by boosting nitric oxide levels in your body. This could lead to better muscle pumps, more endurance, and faster recovery during your workouts. It might also support healthy blood pressure and improve nutrient delivery to your muscles.

    As per the official website, Nutricost Nitric Oxide Booster is non-GMO, Soy-Free, and Gluten-Free, which makes it suitable for various dietary needs. It is also Third-Party Tested for quality and made in a GMP Compliant, FDA-registered facility, ensuring it's safe and effective.

    Pros & Cons of Nutricost Nitric Oxide Booster

    Pros

    • 60 servings per bottle, offering long-lasting value.
    • Non-GMO, Soy-Free, and Gluten-Free, suitable for various dietary needs.
    • 3rd Party Tested for purity and potency.
    • Made in a GMP Compliant, FDA-registered facility for safety and quality.
    • Supports improved blood flow, muscle pumps, and workout endurance.
    • It may enhance recovery time after intense physical activity.

    Cons

    • No direct mention of added ingredients for additional energy or focus.
    • Contains L-arginine, which might cause discomfort and side effects.
    • Limited information is available on the official website related to its benefits.
  5. Snap Supplements Nitric Oxide Booster

    Snap Supplements Nitric Oxide Booster

    Snap Supplements Nitric Oxide Booster claims to support your stamina, heart health, and overall circulatory function. It is said to contain muira puama bark extract, Asian ginseng root, l-citrulline, and l-arginine, which may help support your lung function, promote respiratory health, and improve circulation.

    L-Citrulline in Snap Supplements Nitric Oxide Booster may boost optimal nitric oxide production in your body, which may enhance blood flow, improve muscle endurance, and promote better oxygen delivery to tissues during exercise, helping to boost your overall stamina and performance.

    As per the official website, Snap Supplements Nitric Oxide Booster is vegan-friendly and free from 9 allergens, including sugar, soy, sucralose, and caffeine. It's also gluten-free, non-GMO, and 100% drug-free.

    The makers added muira puama bark extract to the formula, which is known for its adaptogenic properties. It may help reduce fatigue, enhance energy levels, and improve stamina. It's also believed to support mental clarity and focus, which could be beneficial for both physical and cognitive performance.

    Pros & Cons of Snap Supplements Nitric Oxide Booster

    Pros

    • It could help enhance stamina and endurance during physical activities.
    • It may support heart and circulatory health for better cardiovascular function.
    • It claims to promote improved lung function and respiratory health.
    • Contains natural, high-quality ingredients like Muira Puama and Asian Ginseng.
    • Vegan-friendly and free from the big 9 allergens.
    • No added sugar, sucralose, or caffeine.
    • Gluten-free, soy-free, and non-GMO.

    Cons

    • Results could vary, and you may not experience immediate effects.
    • It may not be available in retail shops.
    • If you already have high nitric oxide levels, it might be less effective for you.
  6. Deal Supplement nitric oxide booster

    Deal Supplement nitric oxide booster

    As per the official website, Deal Supplement Nitric Oxide Booster provides you with 3,000mg of strength per serving, including a blend of Arginine and Citrulline, along with an energy blend that contains Tongkat Ali, Korean red ginseng and maca root to keep you energized and support optimal blood circulation in the body.

    Deal Supplement Nitric Oxide Booster may make you feel more alert during your workout by boosting your energy levels. The addition of arginine and citrulline complex in the formula could help improve your blood flow, which means your muscles get more oxygen and nutrients during exercise. This can lead to better pumps and more intense workouts. It may also help increase your endurance, helping you stay consistent without feeling tired or fatigued.

    Made with natural ingredients like 8 amino acids and 4 plant botanicals, Nitric Oxide Booster from Deal Supplement offers 800mg of Arginine Complex, 400mg of Citrulline Complex, and 1,800mg of the Energy Blend in each bottle.

    Pros & Cons of Deal Supplement nitric oxide booster

    Pros

    • It may help you feel more energized during workouts.
    • It could support better pumps and muscle oxygenation for more effective training.
    • It might help enhance blood circulation, benefiting your overall heart function.
    • Includes amino acids and plant botanicals.
    • It is third-party tested and includes lab-tested ingredients.

    Cons

    • Taking 3 capsules per serving could be hectic.
    • You may experience slight stomach discomfort when using the supplement.
    • The benefits of the plant botanicals are not clearly mentioned.
  7. Energievoll Nitric Oxide Supplement

    Energievoll Nitric Oxide Supplement

    Energievoll Nitric Oxide Supplement claims to boost your performance during workouts by improving your stamina and energy levels. It could help boost nitric oxide levels, improving circulation and oxygen delivery to your muscles. This may enhance your endurance and strength for better workout performance.

    Energievoll Nitric Oxide Supplement is said to be 100% natural, vegan, non-GMO, and free from gluten, peanuts, soy, and wheat. Manufactured in high-quality facilities, Energievoll claims to meet strict safety standards.

    Pros & Cons of Energievoll Nitric Oxide Supplement

    Pros

    • Vegan and Non-GMO, which makes it suitable for vegan and non-GMO diets.
    • It could help boost blood flow for better endurance and performance.
    • It may help reduce muscle fatigue, aiding quicker recovery.
    • It is free from common allergens like gluten, soy, wheat, and peanuts.

    Cons

    • Its benefits are mostly tied to exercise performance.
    • Taking three capsules daily might be inconvenient.
  8. Type Zero Clean Pre-Workout Nitric Oxide Booster

    Type Zero Clean Pre-Workout Nitric Oxide Booster

    Type Zero Clean Pre-Workout claims to enhance your stamina and endurance during workouts. With 5000mg of L-Citrulline Malate 2:1 and 2000mg of Arginine AKG 2:1, it may help boost nitric oxide levels, improving blood flow and giving you better muscle pumps.

    The makers added 400mg of Beta-Alanine in the formula, which could help reduce muscle fatigue, letting you push through longer workouts. Clean Pre-Workout from Type Zero is said to be caffeine-free, which may give you an energy boost without causing jitteriness. It's also sugar-free and sweetened with stevia for a healthier option.

    Vitamin C and vitamin B12 in Type Zero Clean Pre-Workout could support your immune system and keep your stamina up during intense sessions. The addition of bioperine in the formula might help your body absorb nutrients more effectively.

    According to the official website, Type Zero Clean Pre-Workout is third-party tested, non-GMO, and gluten-free, ensuring its safety and effectiveness. It is also available in cherry and limeade flavors.

    Pros & Cons of Type Zero Clean Pre-Workout Nitric Oxide Booster

    Pros

    • It is caffeine-free, which makes it suitable to use at any time of the day.
    • Sweetened with stevia, offering a healthier, no-sugar option.
    • Contains beta-alanine to reduce muscle fatigue during workouts.
    • It may help enhance circulation and muscle pumps.
    • It could also support immune function and energy levels.
    • It is non-GMO, gluten-free, and third-party tested for quality.
    • Available in refreshing cherry and limeade flavors.

    Cons

    • Beta-alanine could cause mild bloating or digestive issues.
    • Effects may take longer to appear.
    • You might find the formula costly.

What Are Nitric Oxide Supplements?

Nitric oxide (NO) supplements help support your body's natural production of nitric oxide that keeps your blood vessels healthy. Your body makes NO by converting the amino acid L-arginine into nitric oxide using an enzyme called nitric oxide synthase (NOS).

Once produced, NO moves into the smooth muscle cells of your blood vessels, triggering an enzyme called guanylate cyclase. This may increase levels of cyclic guanosine monophosphate (cGMP) molecule that helps relax blood vessels, improve circulation, and enhance oxygen delivery to your muscles and organs.

NO supplements may also support cell signaling, immune defense, and brain function. They could help nerve cells communicate better, assist immune cells in fighting infections, and promote flexible blood vessels for healthy blood pressure.

Side Effects Of Nitric Oxide Supplements

  1. Low Blood Pressure

    Taking nitric oxide supplements may lower your blood pressure by widening your blood vessels. This can sometimes cause symptoms like dizziness, lightheadedness, and fainting, especially when standing up too quickly. You might also experience blurred vision or feel weak. If your blood pressure drops too much, you may feel weak or confused. This happens because nitric oxide helps your blood vessels open up, which lowers the pressure in your blood vessels.

  2. Headaches

    Headaches can occur when using nitric oxide products because they cause blood vessels in your head to widen. This change in pressure can lead to headaches, often felt in your forehead or temples. If you're you're prone to migraines, nitric oxide might trigger them.

  3. Nausea Or Stomach Discomfort

    You may feel nauseous or experience stomach discomfort after taking nitric oxide. This could happen because the ingredients in the NO supplement might irritate your stomach. Exceeding the maker's suggested dosage might also make you feel bloated or cause indigestion. This discomfort could also occur because nitric oxide can affect digestion by changing the blood flow in your digestive system.

  4. Medical Interaction

    Nitric oxide products might interact with blood pressure medications. They could also interact with blood thinners, as nitric oxide may help open your blood vessels, making it harder for your blood to clot. You might also notice that you bruise more easily or bleed longer than usual. If you're taking medications like warfarin or have a bleeding disorder, you should be cautious when using these supplements.

How To Choose The Best Nitric Oxide Supplement?

  1. Check The Type Of Supplement

    Nitric oxide supplements come in different forms, including capsules, powders, and pre-workout formulas, and choosing the right one depends on your needs and lifestyle. Capsules offer convenience with a precise dosage and require no mixing, making them a simple option, though they may take longer to absorb. Choosing powders provides flexibility, allowing you to adjust the dosage and mix them with water or shakes, and they often absorb faster than capsules. Some Nitric oxide products also come in pre-workout formulas that combine nitric oxide boosters with other performance enhancers, such as caffeine, to improve your energy, endurance, and focus. Make sure to consider these factors, as they may help you stay consistent with your dosage in the long run.

  2. Look For Ingredient Quality

    The quality of components plays a key role in how effective and safe a nitric oxide supplement is. To choose the best option, look for clinically studied and high-purity ingredients that are backed by scientific research. Supplements with proven ingredients tend to support better blood flow, endurance, and performance, while low-quality formulas often contain fillers that provide little to no benefit.

    You should also check for third-party testing and certifications, as these ensure the product meets safety and purity standards. Avoid products with artificial additives, unnecessary fillers, or proprietary blends that hide ingredient dosages. Instead, choose brands that fully disclose their ingredient list and use research-backed dosages.

  3. Dosage And Effectiveness

    The dosage of a nitric oxide formula directly affects its ability to enhance blood flow, oxygen delivery, and muscle performance. To choose the best nitric oxide supplement, look for products that provide clinically validated dosages, as studies suggest that precise amounts are needed to activate nitric oxide production effectively. Underdosed formulas may not sufficiently stimulate endothelial nitric oxide synthase (eNOS), while excessive intake could lead to side effects like low blood pressure or dizziness.

  4. Price And Value

    When choosing a nitric oxide formula, you should compare the price to the quality of ingredients and the number of servings you get. A low-grade or inexpensive supplement under $20 might seem like a good deal, but it could have low-quality ingredients, weak dosages, or unnecessary fillers. On the other hand, an expensive supplement of $40 or more isn't always better, so it's important to check if the ingredients are backed by research and included in the right amounts.

    Look at the cost per serving instead of just the total price to see if you're you're getting good value. Some supplements require multiple servings per day, which can make them more expensive over time. You could also look for brands that offer third-party testing and clear ingredient labels, as these ensure safety and effectiveness. Checking customer reviews and looking for a money-back guarantee can also help you find a suitable supplement.

Frequently Asked Questions

  • Can Nitric Oxide Supplements Help With Vascularity And Muscle Pumps?
    Nitric oxide supplements could enhance vascularity and muscle pumps by improving blood flow to muscles. L-arginine and L-citrulline in these formulas may help relax blood vessels, helping more blood reach your muscles for a fuller, pumped look.
  • What Natural Sources May Help Boost Nitric Oxide Levels?
    Natural sources to boost nitric oxide levels include beetroot, leafy greens (spinach, arugula), citrus fruits, garlic, pomegranate, watermelon (rich in citrulline), and nuts and seeds (high in arginine). These foods could help increase nitric oxide production or protect it from breakdown.
  • Are Nitric Oxide Supplements Suitable For Beginners In Fitness?
    Nitric oxide supplements could be suitable for you if you are a beginner, as they may help improve your workout performance, endurance, and recovery. However, make sure to consult a doctor for more personalized advice.
  • Do Nitric Oxide Supplements Support Muscle Pumps Without Increasing Water Retention?
    Nitric oxide products normally don't cause water retention. They focus on improving blood circulation, providing a clean muscle pump without the bloating. However, make sure to choose a high-quality formula to avoid such complications.

Conclusion

Nitric oxide supplements could offer various benefits, such as improving circulation, enhancing exercise performance, and supporting heart health. We have listed above some of the best nitric oxide supplements, which may help you find the one that fits best for your health goals.

Nitric oxide helps by dilating blood vessels, which could cause a drop in blood pressure. If you already have low blood pressure, this may lead to dizziness, fainting, or other issues related to poor circulation. Thus, make sure to stay mindful of your dosage and discontinue the use immediately if you experience any discomfort.

However, if you're you're looking for natural ways to boost nitric oxide levels, try eating nitrate-rich foods like beets, spinach, and arugula. Regular exercise, especially aerobic activities, could also help increase nitric oxide production. Whether through nutrition, physical activity, or supplementation, maintaining healthy nitric oxide levels may support overall well-being, improve stamina, and promote better cardiovascular function.

Copyright © 2024 LeafSnap

Contact us at [email protected] or follow @leafsnap on Twitter! View our Privacy Policy.

This project was supported in part by NSF Grant IIS-03-25867 (ITR: An Electronic Field Guide: Plant Exploration and Discovery in the 21st Century) and by the Washington Biologists' Field Club.
Any opinions, findings, conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the official views, opinions, or policy of the National Science Foundation (NSF).