DIM supplements could help support a balance between hormones like estrogen and testosterone, which naturally fluctuate with age. These benefits might help minimize signs of hormone imbalances, such as fatigue, mood swings, or acne.
These supplements contain diindolylmethane, a natural compound found in cruciferous vegetables like broccoli and kale. They may support healthy estrogen metabolism, reduce inflammation, and promote vitality.
While diet provides some DIM, supplements may provide a concentrated dose if you seek consistent hormonal support. To help you make an informed choice, we have reviewed and curated a list of the 10 Best DIM Supplements in 2025.
As per its official site, NutraBio's Wellness DIM provides 100 mg of Diindolylmethane (DIM), 500mg of calcium-D-glucarate, and 5mg of BioPerine per capsule. It could support the metabolism of estrogen into balanced forms, which may benefit energy, mood, and body composition over time.
Calcium-D-glucarate in NutraBio may help your body break down and remove excess estrogen. The process may support liver detoxification and potentially lower the risk of estrogen-related issues like thyroid disorders, irritability, or hormonal imbalances.
The makers state that NutraBio DIM follows full label disclosure, listing every ingredient and dosage without proprietary blends. It is also free from harmful compounds like fillers, chemical additives, BSE/TSE, and GMOs.
According to its official site, NutriFlair DIM + BioPerine offers 400 mg of diindolylmethane (DIM) and 5 mg of BioPerine per capsule. By supporting hormone balance, NutriFlair DIM may assist in maintaining steady levels of estrogen, testosterone, and progesterone hormones.
NutriFlair's Premium DIM + BioPerine may provide benefits like mood stability, increased energy levels, and improved skin health. It might also help minimize the symptoms associated with menopause or prostate changes, such as irritability, decreased libido, brain fog, or urinary issues.
NutriFlair – Premium DIM + BioPerine provides 120 capsules per bottle, and the makers suggest consuming one capsule daily with a meal.
DIM Complex by Puritan's Pride features diindolylmethane (DIM), a compound naturally produced when your body digests the indole-3-carbinol compound. Each capsule provides 100 mg of a DIM® Blend Complex, including 25 mg of standardized DIM to support endocrine health.
According to Puritan's Pride, the DIM Complex undergoes extensive testing and inspections throughout the manufacturing process, which may indicate adherence to product consistency, potency, and safety in every batch.
SMNutrition DIM 300 Complex utilizes diindolylmethane to help convert potent estrogens in the body into less active forms, promoting a healthier testosterone-to-estrogen ratio. The balance may support better muscle development and improved energy levels.
SMNutrition DIM 300 Complex's one-capsule serving provides 100mg of calcium D-glucarate and 100mg of broccoli floret powder. Calcium D-glucarate may support the liver's natural detoxification processes and help your body eliminate metabolized hormones. The process may contribute to improved focus and sustained energy throughout the day.
SMNutrition DIM 300 Complex also contains BroccoPhane and Activated BroccoRaphanin, two broccoli-derived extracts rich in sulforaphane. These extracts have antioxidant effects that may support cellular health and detoxification pathways. BioPerine (black pepper extract) is also included to improve nutrient absorption.
The makers state that SMNutrition DIM 300 Complex undergoes third-party testing and is free from gluten, GMOs, and the top eight allergens. It is also vegetarian-friendly and PETA-certified, providing you with a cruelty-free and clean formula.
NOW DIM 200 Veg Capsules may help contribute to hormonal balance by supporting efficient estrogen metabolism. It features Diindolylmethane (DIM), a compound formed when your body processes cruciferous vegetables like broccoli, Brussels sprouts, and cabbage.
Calcium D-glucarate in DIM 200 may complement diindolylmethane's effects in supporting hormone metabolism. NOW DIM 200 Veg Capsules also contain sodium copper chlorophyllin. It is a stabilized form of chlorophyll, which provides antioxidant support and promotes the body's natural cleansing processes.
NOW DIM 200 Veg Capsules provide 90 capsules in each bottle and are third-party tested for safety and purity by reputable labs like Intertek.
DIM-Evail™ by Designs for Health provides 100 mg of highly absorbable Diindolylmethane (DIM) in each softgel to support hormonal balance.
The DIM in DIM-Evail™ may support the production of 2-hydroxyestrone, a beneficial estrogen metabolite associated with a healthier 2:16 hydroxyestrone ratio. This could support a healthier balance between different types of estrogen in your body.
DIM-Evail™ uses an advanced delivery system by combining medium-chain triglycerides (MCTs), quillaja extract, and tocotrienols. The combination may enhance DIM uptake without synthetic emulsifiers or surfactants. You may also benefit from DIM's ability to support a healthy inflammatory response.
As per its official site, Nutricost DIM capsules feature 300 mg of Diindolylmethane (DIM) per capsule, offering potent support for estrogen metabolism. Each Nutricost DIM bottle contains 120 vegetarian capsules, providing a two-month supply at a once-daily serving.
Nutricost DIM capsules also contain 5mg of BioPerine, a patented black pepper extract known to support better nutrient uptake. The manufacturers of Nutricost also back their DIM capsules with a 60-day money-back guarantee.
Thorne Hormone Advantage, previously called DIM Advantage, could help maintain a healthy estrogen balance. Each capsule provides 150mg of Diindolylmethane (DIM), 100mg of pomegranate extract, and 25mg of sulforaphane glucosinolate (SGS) from broccoli seed extract.
For women, Thorne Hormone Advantage might help minimize hormone-related symptoms like mood swings, fatigue, and bloating, especially around the menstrual cycle. It could also support breast, cervical, and uterine health while helping maintain a favorable estrogen profile.
Thorne Hormone Advantage may also support a healthy balance between estrogen and testosterone levels in men. Such effects might help improve energy levels, reduce weight retention, and promote prostate health.
DIM SGS+ by BioTE features extracts from broccoli and pomegranate to support balanced estrogen metabolism. It also includes diindolylmethane (DIM) and sulforaphane glucosinolate (SGS), which help offer supportive roles in hormonal balance.
As hormone levels shift with age, imbalances in estrogen and testosterone hormone levels might contribute to concerns like weight gain, bloating, and water retention. BioTE claims that its DIM SGS+DIM could help minimize such risks by promoting a healthier ratio between estrogen and its metabolites.
As per its official site, each serving (2 capsules) of Xymogen's DIMension 3 features 150mg of diindolylmethane (DIM) and 62mg of calcium, which could promote the breakdown of estrogen into beneficial metabolites to minimize imbalances.
It also contains 250mg of turmeric extract and 2.5mg of black pepper extract. These ingredients have potent anti-inflammatory and antioxidant effects, which could also help enhance the bioavailability of DIM in your body. Each bottle of Xymogen DIMension 3 provides 120 capsules. The makers suggest taking a recommended dose of 2 capsules daily to achieve targeted hormone support.
DIM helps convert estradiol (a potent form of estrogen) into 2-hydroxyestrone, a weaker estrogen linked to protective effects against hormone-related cancers. It also helps reduce the levels of harmful metabolites like 16-alpha-hydroxyestrone. These two processes can contribute to hormonal shifts, which may trigger symptoms like mood swings, irritability, fatigue, decreased libido, weight gain, dry skin, or insomnia.
DIM supplements aid in metabolizing and eliminating excess estrogen and related metabolites through the liver. The process may cause a temporary surge in hormonal activity and toxin elimination, leading to potential skin reactions.
If your liver detoxification pathways are not functioning optimally, the body may push toxins or metabolites through alternative routes, such as the skin. This may result in rashes, hives, itchiness, or acne-like breakouts, usually on the chest, back, or arms.
A common side effect of DIM supplementation is darkened urine, which may appear tea-colored, amber, or brownish-yellow. It could happen because DIM metabolites (particularly indole derivatives) are processed in the liver and excreted through the kidneys, which may give the urine a noticeably darker shade. While dark urine might be concerning, it is generally a benign occurrence and does not indicate liver or kidney damage.
DIM supplement's role in estrogen metabolism might contribute to temporary or noticeable changes in the menstrual cycle, particularly in the early stages.
As DIM alters estrogen metabolite ratios, some women may experience shorter or longer cycles, lighter or heavier periods, or spotting between periods. For women with estrogen dominance, DIM supplements may cause irregular cycles.
Women with conditions like PCOS or irregular ovulation may see either improvements or temporary irregularities.
DIM supplements may temporarily increase the liver and other detoxification organs' workload, potentially leading to fatigue. The effects could be more pronounced if you have underlying nutrient deficiencies (like B vitamins, magnesium, or iron), are under stress, or lack quality sleep.
Hormonal shifts, particularly rapid decreases in estrogen, can affect neurotransmitters like serotonin and dopamine. Such interactions might also contribute to feelings of sluggishness, brain fog, or general tiredness.
Headaches (typically mild to moderate) are common during the first few days or weeks of DIM supplementation. These headaches are often triggered by changes in estrogen levels, which may influence blood flow and pain sensitivity.
The estrogen hormone helps modulate blood vessel dilation and constriction, and a sudden shift in estrogen or its metabolites may trigger headaches or migraines. DIM's detoxification process may also create a temporary burden on the liver and kidneys, contributing to tension headaches or dull aches
Digestive discomfort, like bloating, gas, stomach cramps, nausea, or fullness, is common when starting DIM supplementation. DIM stimulates liver detoxification and alters hormone metabolism, which could increase bile production or disrupt the gut microbiome.
Such interactions may trigger digestive upset, particularly if you have gastrointestinal problems such as leaky gut or IBS. In rare cases, nausea may also occur if DIM supplements are taken on an empty stomach or with insufficient water.
In evaluating the best DIM supplements, the pricing, dosage, and value are the key factors. Nutricost DIM Capsules appear as a budget-friendly option, offering one bottle (120 capsules) at $19.97. NutraBio Wellness DIM follows closely at $19.99 for 60 capsules, offering good quality but at a slightly higher cost per capsule than Nutricost.
NutriFlair's Premium DIM + Bioperine costs $20.99 for one bottle with 120 capsules, delivering 400mg of DIM per capsule. Now's DIM 200 Veg Capsules cost $23.99 for 90 capsules, but its lower 200mg DIM dosage per capsule could make it less potent.
SM Nutrition's DIM 300 Complex is priced at $29.95 for a single bottle with 60 capsules, providing a decent 300mg DIM dosage per capsule. However, its fewer capsules per bottle place it in the mid-range for value.
Designs for Health DIM-Evail costs $35.25 for 60 softgels, which offers a softgel format. However, it comes at a higher price and a 200mg DIM dose, making it less cost-effective. On the other hand, Puritan's Pride DIM Complex, priced at $40.99 for two bottles (120 capsules total), provides excellent value with its Buy 1 Get 1 Free offer.
THORNE Hormone Advantage is priced at $47 for one bottle (60 capsules), positioning itself as a premium option but with a steep cost per dose. Biote DIM SGS+ is priced at $57 for 60 capsules, offering no clear additional benefits for its high price.
Moreover, Xymogen's DIMension 3 Capsules costs $62.99 for a bottle with 120 capsules. Despite DIMension 3's large bottle size, its pricing is hard to justify without any significant added benefits.
In evaluating the best DIM supplements, assessing the return policy may help determine customer satisfaction and the flexibility of the products.
NutraBio stands out with its “Forever & A Day Guarantee,” allowing refunds or exchanges within 90 days of purchase, regardless of when the product was bought. NutraBio's policy provides the highest level of flexibility and ensures customer satisfaction.
Puritan's Pride also offers a 90-day return window, allowing returns on both opened and unopened products. The generous timeframe and flexible policy could make it one of the most customer-friendly DIM supplement options.
SM Nutrition offers a 100% money-back guarantee with no questions asked, which may be appealing to customers seeking a risk-free purchase. However, the lack of a specified return window makes it less clear than the return policies of other DIM brands we evaluated.
Nutricost provides a 60-day return policy, allowing returns of items in new condition after the first bottle. While there are some restrictions, the extended return period may give customers ample time to evaluate the product. THORNE's 60-day refund period is reasonable but not as generous as others.
Designs for Health provides a 30-day return window with proof of purchase. However, exclusions for certain items, such as private label or heat-sensitive products, may limit its flexibility.
Biote's 30-day satisfaction guarantee is solid but may feel restrictive for those needing more time to assess the product. Now Food's 30-day return policy is straightforward but requires you to cover return shipping costs, which could be a downside for some buyers.
NutriFlair's 30-day money-back guarantee applies only to first-time purchases or one unit of the product. Xymogen's return policy is the most restrictive, only accepting returns in cases of damage, shortages, or incorrect items, with claims required within five days of delivery. Its short return window and rigid policy limit customer satisfaction.
When evaluating the best DIM supplements in 2025, brand reputation could help ensure product quality and customer satisfaction.
NutraBio stands out with an impressive Trustpilot rating of around 4.9 out of 5, based on over 1,050+ reviews. Its high Trustpilot score may reflect NutraBio's dedication to transparency, high-quality ingredients, and superior customer service.
Similar to NutraBio, NutriFlair follows with a Trustpilot rating of 3.7 out of 5, based on 840+ reviews. While the feedback is generally positive, there is some variation in customer experiences, particularly occasional concerns about product consistency and service.
Puritan's Pride has a concerning Trustpilot rating of 1.5 out of 5, based on 270+ reviews. Its low rating may indicate significant dissatisfaction with product quality and customer service, raising red flags for potential buyers.
Other DIM brands, like SM Nutrition, Now Foods, Designs for Health, Thorne, Biote, and Xymogen, either lack Trustpilot ratings or have not claimed their profiles. While these brands have established themselves over time, the absence of user feedback on Trustpilot makes it difficult to assess their reputation.
DIM (diindolylmethane) supplements may have the potential to support hormonal balance, particularly in tackling estrogen dominance and improving the testosterone-to-estrogen ratio. They may also support estrogen metabolism and support the body's natural detoxification processes.
The 10 best DIM supplements listed above could help support cellular health, promote immune function, improve energy levels, and aid liver health. However, overuse of DIM supplements may trigger side effects like hormonal fluctuations, digestive discomfort, skin rashes, and changes in menstrual cycles. These effects may vary from person to person. Moreover, the long-term studies on the safety of DIM supplementation are also limited.
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