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6 Best Colostrum Supplements In 2025

Colostrum supplements claim to support your body's immune system. They may also provide digestive support by maintaining gut integrity and may ease issues like leaky gut. They aid in muscle recovery and inflammation control, while they could also enhance skin health and slow the aging process.

However, with so many colostrum supplements on the market, how do you know which one could work? It's essential to learn about sourcing, processing methods, purity, and added ingredients.

To simplify your search, we've discussed 6 best colostrum supplements available in the market. This exclusive guide will help you understand in detail about Colostrum supplements, their side effects, and factors to look for when choosing the best colostrum supplement.

6 Best Colostrum Supplements

  1. N°1 Colostrum Pro

    N°1 Colostrum Pro

    The N°1 Colostrum Pro, as detailed by the makers on the official site, contains defatted bovine colostrum powder as its primary ingredient. It has essential nutrients and antibodies, especially Immunoglobulin G (IgG), which helps in boosting the immune system. According to the official site, the colostrum powder in N°1 Colostrum PRO contains 30% IgG. Each capsule is said to contain 800 mg of defatted bovine colostrum powder, providing 240 mg of IgG per 2-capsule serving. N°1 Colostrum Pro also contains hydroxypropyl methylcellulose and Silica, which is sourced from bamboo leaf extract (Bambusa vulgaris) and used as an anti-caking agent to prevent clumping.

    Pros

    • It helps strengthen your immune system with key antibodies like IgG.
    • It promotes healthy gut function by supporting the growth of beneficial bacteria.
    • The product uses plant-based ingredients like Hydroxypropyl Methylcellulose and Silica.
    • Each bottle provides a 30-day supply.
    • The capsules are easy to swallow, with no strong aftertaste.

    Cons

    • At $27.00 for one bottle, it could be on the expensive side if you're on a tight budget.
    • Unsuitable for those with milk allergies.
  2. Bio-Avail Colostrum+

    Bio-Avail Colostrum+

    Manufactured by Avail Naturals, Bio-Avail Colostrum+ contains grass-fed bovine colostrum, lactoferrin, and beta-glucan, which can support your gut, iron metabolism, and immunity.

    According to the makers, Bio-Avail Colostrum+ helps boost and balance your immune system by supporting mucosal barriers in your gut, skin, and lungs, protecting you from pathogens, toxins, and allergens.

    The Bio-Avail Colostrum+ contains antibodies and growth factors that are believed to enhance your immune defenses. It claims to nourish your microbiome by providing beneficial prebiotics, immune factors, and beta-glucans that promote healthy gut bacteria while reducing harmful microbes.

    With beta-glucans, Bio-Avail Colostrum+ is said to support a healthy immune function, restoring balance and allowing your immune system to respond more effectively to threats rather than overstimulating it.

    Bio-Avail Colostrum+ also claims to promote vitality, supporting radiant skin, healthier hair and nails, and improved energy levels. It is made with clean, natural ingredients, free from GMOs, gluten, and harmful chemicals.

    However, you should avoid mixing Bio-Avail Colostrum+ with hot beverages, as high temperatures can degrade its protein. Moreover, if you have metabolic issues or prefer taking it on an empty stomach, the makers recommended mixing Bio-Avail Colostrum+ powder with room-temperature water 30 minutes before or 2 hours after a meal. They also mention that Bio-Avail Colostrum+ contains a higher dose of 100 mg of pure lactoferrin, offering 107.5 to 112.5 mg per 1 scoop of 2.8 grams serving.

    Pros

    • Aids in balancing beneficial bacteria in the gut for better digestion and gut function.
    • May help in promoting healthier skin, hair, and nails.
    • Manufactured with clean ingredients and undergoes rigorous third-party testing for quality assurance.
    • The packaging is also compostable and recyclable to help reduce plastic waste.
    • It comes with a 60-day money-back guarantee.
    • It comes with free shipping on orders above $85.

    Cons

    • Bio-Avail Colostrum+ may trigger flatulence and upset stomach.
    • It contains lactoferrin, which can trigger skin rashes and constipation.
  3. Amra Colostrum

    Amra Colostrum

    As per its official site, Amra Colostrum is sourced from grass-fed cows on family dairy farms in the USA. It claims to strengthen and rebuild your body's mucosal barriers. The makers claim that Amra Immune Revival Colostrum is made using Cold-Chain BioPotent™ Pasteurization Technology to preserve the bioactive compounds and ensure potency. It contains 400 bioactive nutrients that can strengthen immunity, gut health, metabolism, and skin radiance. Amra Colostrum includes immunoglobulins, prebiotics, peptides, antioxidants, and antimicrobials, all of which can improve digestion, enhance energy, and promote muscle recovery, skin rejuvenation, and hair growth. It is free from sugars, gluten, GMOs, hormones, antibiotics, and artificial additives, and it's tested for safety and purity by third-party laboratories.

    Pros

    • It boosts your immune system by providing antibodies to fight infections.
    • It helps with digestion, reduces bloating, and strengthens the gut.
    • It helps boost energy levels and supports metabolism.
    • It promotes skin health, improves elasticity, and encourages hair growth.
    • Supports muscle repair and recovery, helping after workouts.
    • It is free from sugars, gluten, GMOs, hormones, antibiotics, and artificial additives.
    • It's third-party tested for safety and purity by independent labs.
    • Available in Sungold apricot, blood orange, and vine watermelon flavors with travel-friendly options.

    Cons

    • It is available for $109.99 for 120 powder servings, which can be expensive for some people, especially for regular use.
    • Some people might not like the taste, even though there are flavored options.
    • People with dairy problems or sensitivities should avoid it.
    • You can only return it if the seal is unopened, which can be inconvenient if you don't like it after trying it.
  4. Doublewoods Colostrum

    Doublewoods Colostrum

    Doublewoods Colostrum is rich in nutrients, growth factors, antibodies (immunoglobulins), and other bioactive compounds that are essential for immune health. It is claimed to be sourced from grass-fed cows and is standardized to contain 15% immunoglobulins, which support immune function. Each capsule contains 500mg of colostrum, with the makers's recommended dosage being two capsules daily (1,000mg). Its growth factors, like IGF-1, may support your muscle recovery, digestive health, bone health, and cognitive function. As per the official site, Doublewoods Colostrum also has certificates of analysis and third-party test results that may indicate transparency, allowing you to check its quality and potency.

    Pros

    • It helps heal and support your digestive system.
    • The growth factors in colostrum help muscles recover and grow after physical activity.
    • The antibodies in colostrum help improve your immune system, protecting your body against infections.
    • At $19.95 for a one-month supply, it's more reasonably priced than similar products.
    • It may support strong bones and healthy joints.
    • The supplement is made and tested in the USA.
    • It is free from GMOs, gluten, and soy.
    • It may improve your brain function, including memory and focus.
    • You can get a full refund within 30 days.

    Cons

    • Some people might experience mild digestive discomfort, like bloating.
    • Some people may find it difficult to swallow these capsules.
  5. Grass Fed Beef Colostrum

    Grass Fed Beef Colostrum

    Grass-Fed Beef Colostrum claims to support immune function and cellular regeneration. It contains antibodies that may help fight infections and prevent illness, as well as proline-rich polypeptides (PRPs), lactoferrin, glycoproteins, and cytokines. These componds may help in strengthening the body's defenses.

    The makers also mention that Grass-Fed Beef Colostrum contains growth factors that promote healing, tissue repair, and cellular regeneration. These include epithelial growth factor (EGF), insulin-like growth factors I & II (IGF-I & IGF-II), transforming growth factors A & B (TGF A & B), and platelet-derived growth factor (PDGF).

    Grass-Fed Beef Colostrum delivers essential vitamins, minerals, enzymes, and amino acids that contribute to gut function. Sourced from pasture-raised cows from New Zealand and Australia, it is 100% grass-fed and grass-finished, ensuring a clean and high-quality product. Free from hormones, pesticides, GMOs, fillers, and flow agents, Grass-Fed Beef Colostrum is carefully processed through freeze-drying or low-temperature spray drying to maintain its bioactive properties while remaining non-defatted. Every 6-capsule serving of Grass-Fed Beef Colostrum contains 3000mg of premium bovine colostrum encapsulated in gelatin capsules.

    Pros

    • Supports muscle recovery and strength with growth factors that help repair tissues and cells.
    • Helps digestion and may reduce bloating or stomach discomfort.
    • Strengthens the immune system by delivering antibodies and essential nutrients to fight infections.
    • Promotes healthy skin and wound healing by aiding in cell and tissue repair.
    • Contains a mix of vitamins, minerals, enzymes, and amino acids.
    • Free from artificial fillers, flow agents, and harmful chemicals, with third-party testing for purity and safety.

    Cons

    • Can cause mild stomach discomfort, such as bloating, when first introduced into the diet.
    • Can be expensive compared to other similar supplements on the market.
  6. Wondercow Colostrum Powder

    Wondercow Colostrum Powder

    Wondercow Colostrum Powder is made from 100% pure bovine colostrum. According to the makers, their colostrum powder is rich in antibodies, growth factors, vitamins, and more than 200 bioactive ingredients that help support gut health, immune function, and muscle recovery.

    Wondercow Colostrum Powder claims to improve digestion, strengthen immunity, and also support muscle recovery. You can mix it into water, smoothies, coffee, yogurt, or any beverage of your choice. Each Wondercow Colostrum Powder container provides 60 servings.

    As per the official site, Wondercow Colostrum Powder undergoes rigorous testing and certifications to ensure purity and safety. It is gluten-free, tested for pesticides and glyphosate, and screened for heavy metals. Wondercow Colostrum Powder is also regulated by the United States Department of Agriculture (USDA), the National Animal Supplements Council (NASC), and Low Risk Veterinary Health Products (LRVHP), ensuring adherence to strict quality and safety standards.

    Pros

    • The powder contains probiotics, which can support a healthy gut by promoting good bacteria.
    • Its antibodies help strengthen your immune system, potentially making it easier to fight off infections.
    • The growth factors in colostrum can help with muscle repair, which can be helpful after exercise.
    • Wonderchow Colostrum Powder comes with a 60-day satisfaction guarantee.
    • It comes in elderberry, chocolate, and unflavored options.

    Cons

    • At $64.99 for 60 servings, it might be considered expensive compared to other colostrum products.
    • People with hormone sensitivity should refrain from using it.

How Do Colostrum Supplements Work?

Colostrum supplements may work by delivering a concentrated dose of bioactive compounds that support immunity, gut health, and muscle recovery. These supplements contain essential components like immunoglobulins, growth factors, lactoferrin, and probiotics.

Colostrum supplements may also help strengthen the immune system. Their formulation contains immunoglobulins (IgG, IgA, IgM) antibodies that may help neutralize harmful bacteria, viruses, and toxins, enhancing the body's natural defenses. The makers of these supplements also add lactoferrin, which can aid in immune regulation with its antimicrobial and anti-inflammatory properties, decreasing the risk of infections and promoting immune balance.

Colostrum supplements contain cytokines, polypeptides, and antioxidants, which can boost collagen production, improve skin elasticity, and repair damaged skin. Their anti-inflammatory and antioxidant properties help combat signs of aging, promoting a healthier and youthful appearance.

The makers of colostrum supplements also claim that including them in a daily routine can help you experience enhanced immunity, improved gut health, faster muscle recovery, and healthier skin.

Side Effects Of Colostrum Supplements

  1. Could Be Contaminated with Harmful Substances

    Since colostrum is derived from cows, it might be exposed to antibiotics, pesticides, or hormones used in dairy farming. If the colostrum supplement is not sourced from high-quality, grass-fed cows or lacks proper testing, you could be consuming harmful residues. Instead of supporting your health, contaminated colostrum supplements may introduce toxins into your body, causing more harm than good.

  2. Might Cause Hormonal Imbalances

    The growth factors in colostrum could alter hormone levels, which may lead to unintended effects such as acne, mood swings, or irregular menstrual cycles. If your body is sensitive to hormonal changes, taking colostrum supplements might disrupt your system instead of improving it.

  3. May Interfere with Medications

    If you take prescription medications, colostrum supplements might disrupt their effectiveness, leading to unexpected health complications. Those on immune-suppressing drugs could experience immune overactivity, while people with diabetes may face blood sugar fluctuations. Growth factors in colostrum could also interfere with hormonal treatments or cancer therapies, making colostrum supplements unsafe if you have a medical condition.

  4. Might Trigger Allergic Reactions

    If you have a dairy allergy, colostrum supplements could lead to severe allergic reactions, including itching, swelling, rashes, or difficulty breathing. Even trace amounts of dairy proteins in these supplements might be enough to cause a reaction, making them risky for anyone with sensitivities. They could put you in danger of an unexpected and potentially life-threatening allergic response.

  5. May Cause Digestive Discomfort

    You might experience bloating, gas, nausea, or diarrhea after taking colostrum supplements, especially if you have lactose intolerance or a sensitive digestive system. The high protein content could overwhelm your stomach, leading to cramps and irregular bowel movements. Instead of improving gut health, colostrum supplements may cause persistent stomach issues that disrupt your daily life.

  6. Could Lead to Flu-Like Symptoms

    Instead of feeling more energized, you might develop headaches, fatigue, body aches, or even nausea after taking colostrum supplements. This reaction could be due to immune overstimulation or a detox effect that makes you feel worse, making you feel drained of your energy levels.

How To Choose The Best Colostrum Supplement?

  1. Check the Source and Quality

    If colostrum comes from factory-farmed cows, you might end up consuming harmful substances instead of getting the health benefits you expect. These cows are often kept in crowded, stressful conditions and are regularly given antibiotics and hormones to prevent illness and increase milk production. Because of this, traces of these chemicals could end up in the colostrum, which might disrupt your body's natural balance and reduce the supplement's effectiveness.

    Factory-farmed cows are also fed low-quality, grain-based diets that may contain pesticides, genetically modified ingredients, or artificial additives. Poor nutrition in cows leads to lower-quality colostrum, meaning you might not get the full range of nutrients your body needs for immune support, gut health, and overall wellness. Instead of a powerful, nutrient-rich supplement, you could be taking something that lacks key bioactive compounds and doesn't provide the results you're looking for.

    Another concern with low-quality colostrum is the risk of contamination. Factory-farmed colostrum may contain harmful bacteria, heavy metals, or toxins that could make the supplement unsafe. Without strict quality testing, these contaminants could go unnoticed, leading to potential digestive issues, immune problems, or other negative health effects.

    To avoid these risks, always choose colostrum from grass-fed, pasture-raised cows, as they produce higher-quality, more nutrient-dense colostrum. Look for supplements that are free from antibiotics, hormones, and artificial additives to ensure you're getting a pure and effective product.

  2. Look for Proper Processing Methods

    Many colostrum supplements undergo high-heat processing, which could strip away the very nutrients that make colostrum beneficial in the first place. Immunoglobulins, growth factors, and other bioactive compounds are heat-sensitive, meaning that excessive temperatures can break them down or render them ineffective. If your supplement has been processed at high heat, you might be consuming little more than a protein powder with diminished immune and gut-supporting properties.

    When colostrum is exposed to extreme heat, its molecular structure changes, causing key components like lactoferrin, antibodies, and enzymes to degrade. As a result, the supplement you're taking may no longer provide the immune-boosting, gut-healing, or muscle-recovery benefits that colostrum is known for. Instead of strengthening your body, an improperly processed supplement could leave you with minimal or no health improvements, making your investment in colostrum essentially worthless.

    Additionally, high-heat processing can reduce the bioavailability of colostrum, meaning your body may struggle to absorb and utilize the remaining nutrients. Even if some beneficial compounds survive the heat, they might be altered in a way that makes them less effective or harder for your body to recognize and use. This could lead to poor digestion, reduced immune support, and an overall weaker impact on your health.

    To ensure you're getting the full benefits of colostrum, choose supplements that use cold-processing or low-temperature drying methods. These techniques preserve the delicate bioactive compounds, keeping the colostrum as close to its natural state as possible. If a supplement doesn't specify its processing method, you could be purchasing a product that has lost much of its potency, ultimately wasting your time and money.

  3. Check for Third-Party Testing

    Without third-party testing, you might be taking colostrum that contains harmful bacteria, heavy metals, or toxins without even knowing it. Some companies skip proper testing to save money, which means their products might not meet safety or quality standards. Instead of helping your health, these supplements could expose you to dangerous contaminants.

    If a supplement isn't independently tested, there's no way to be sure that the label matches what's actually inside. Some colostrum supplements may be weak or ineffective because they don't have enough immunoglobulins, growth factors, or other important nutrients. Worse, some products might contain fillers, artificial additives, or hidden ingredients that could reduce their benefits or cause unwanted side effects.

    To stay safe, always choose colostrum supplements that independent labs have tested. Third-party testing makes sure the product is pure, safe, and contains the right amount of active ingredients. A well-tested supplement is much more likely to be effective, trustworthy, and worth your money.

  4. Avoid Unnecessary Additives and Fillers

    Colostrum supplements that contain artificial flavors, colors, preservatives, or fillers might expose your body to unnecessary chemicals that do more harm than good. These additives are often used to improve taste, appearance, or shelf life, but they offer no real health benefits. Instead of improving the supplement, they might interfere with how your body absorbs and utilizes the key nutrients in colostrum.

    Some of these artificial ingredients might trigger allergic reactions or cause digestive issues like bloating gas or stomach discomfort. If you have sensitivities or food allergies, these additives could lead to unexpected side effects, making the supplement difficult for your body to tolerate. Additionally, preservatives and fillers could dilute the potency of colostrum, meaning you're receiving fewer essential nutrients and reduced benefits.

    To avoid these risks, always choose a clean, high-quality colostrum supplement with minimal ingredients. Look for products that are free from artificial additives, fillers, and synthetic chemicals to ensure you get the purest and most effective form of colostrum.

  5. Check Immunoglobulin (IgG) Content

    Some colostrum supplements have low levels of Immunoglobulin G (IgG), which means they might not give you the immune support you expect. IgG is the main antibody in colostrum that helps fight off bacteria, viruses, and toxins. If a supplement has too little IgG, it could be ineffective, and your immune system won't get the extra protection it needs.

    Many brands don't clearly show the IgG content, so you might unknowingly buy a product that doesn't have enough immune-boosting power. Without enough IgG, colostrum won't provide the infection-fighting, anti-inflammatory, and gut-healing benefits that make it so helpful. A supplement with low IgG could end up being a waste of money.

    To make sure you're getting a high-quality colostrum supplement, always check the IgG percentage on the label. The best products have at least 30-40% IgG, which gives you strong immune support and health benefits. Anything less might not work as well, so it's important to choose a strong and effective supplement.

  6. Choose the Right Form

    Colostrum supplements in pill form can be difficult to take daily if you have trouble swallowing capsules. If you find pills uncomfortable or hard to swallow, it may become challenging to keep up with your daily routine. On the other hand, colostrum powder can have an unpleasant taste or may not mix well with liquids, making it less enjoyable to consume. If you don't choose the right form for your needs, it could become inconvenient to use regularly, leading to missed doses and reduced benefits. Choosing a form of colostrum that's easy and enjoyable for you to take is key to ensuring you get the full health benefits.

  7. Check for Bovine-Specific Certifications

    If the colostrum isn't certified as bovine-derived, you could end up with a product from other animals or mixed with synthetic ingredients. Poor labeling or a lack of clear information might trick you into buying a lower-quality supplement that won't give you the benefits you want. Always check that the product is labeled as 100% bovine colostrum and has certifications for purity and ethical sourcing.

    By paying attention to these details, you can avoid wasting money on supplements that don't work or are contaminated. It's important to make sure you're getting a high-quality product that will actually support your health. If you don't check carefully, you might waste money or even harm your health with a product that doesn't work or has harmful additives.

Frequently Asked Questions

  • Can colostrum supplements help with joint pain?
    Colostrum supplements may help support joint health by reducing inflammation, but they are not specifically formulated for joint pain relief.
  • Are colostrum supplements GMO-free?
    High-quality colostrum supplements often come from grass-fed cows that are free from GMOs. Always check labels for verification.
  • Is there a difference between Whole Food Colostrum Versus Defatted Colostrum Supplements?
    Yes. Whole food colostrum supplements, like Bovine Colostrum, retain fats, immunoglobulins (IgG), growth factors (IGF-1), and lipids. Defatted colostrum supplements, such as Defatted Bovine Colostrum, have the fat removed, lowering calories, but lack A, D, E, and K fat-soluble vitamins and essential fatty acids.

Final Words

Selecting the best colostrum supplements makes it necessary to carefully weigh the factors we've discussed, such as formulation, sourcing quality, and specific product benefits. We've reviewed the six best colostrum supplements, focusing on the presence of immunoglobulins (IgG) and growth factors while considering the method of processing.

While colostrum supplements can support gut health and immunity, it's essential to remain mindful of possible side effects, including digestive issues and allergy breakouts. It's also important to focus on following an active lifestyle and not entirely depend on Colostrum Supplements. Regular exercise, consuming white navy beans and walnuts, and adequate hydration can help in maintaining a healthy gut function. Moreover, you can also consider adding turmeric and ginger as their anti-inflammatory effects and support a better immune function. Also, remember that an individual's response can vary, so it's important to see how your body reacts and consider personal factors when choosing colostrum supplements.

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This project was supported in part by NSF Grant IIS-03-25867 (ITR: An Electronic Field Guide: Plant Exploration and Discovery in the 21st Century) and by the Washington Biologists' Field Club.
Any opinions, findings, conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the official views, opinions, or policy of the National Science Foundation (NSF).