ProHealth claims to support fitness, vitality, and longevity. Its product range includes NAD⁺ and NMN products, cellular energy blends, antioxidants, adaptogens, and foundational nutrients that may support physiological functions associated with aging and daily metabolic demand.
The brand’s offerings focus on biological systems such as cellular energy production, oxidative balance, immune regulation, and metabolic support. It states that its products can support stress response, recovery, and functional stability.
In this review, we will examine ProHealth’s product offerings, assess the brand’s positioning and advantages, and identify its limitations. We will also look at how the brand is viewed within the longevity market.
ProHealth is a longevity-focused brand that concentrates on how the body ages, particularly after 40. The brand operates in the healthy aging and cellular wellness space, with its product lineup built around energy metabolism, DNA repair, and age-related cellular decline.
As per its official website, ProHealth is widely known for its NAD+ and NMN products. Its NMN Pro line uses the patented Uthever® NMN and is available in different strengths and formats, including 300 mg, 500 mg, and 1000 mg capsules as well as powder options.
The brand also offers combination formulas designed to support multiple aging pathways at the same time. Its products, such as NMN Pro Complete, combine NMN with trans-resveratrol and TMG to support NAD+ production, sirtuin activity, and methylation processes.
ProHealth also sells standalone options like Trans-Resveratrol Plus, which is positioned around mitochondrial function, oxidative stress, and DNA protection, keeping the focus on cellular-level aging support. According to the official website, the brand highlights FDA-registered GMP manufacturing, U.S.-based lab testing, and third-party testing for purity and potency.
NMN Pro™ Complete Powder may support cellular energy, metabolic balance, and age-related biological processes. The formula centers on Uthever® B-Nicotinamide Mononucleotide (NMN), a direct precursor to NAD+ required for mitochondrial energy production, DNA repair, and many enzymatic reactions that decline with age.
Uthever® NMN works by entering cells and being converted into NAD+ through the salvage pathway. It might help regulate inflammation, mitochondrial function, and gene expression. These processes influence how efficiently muscles generate energy, how heart cells manage oxidative stress, and how tissues maintain structural integrity over time.
NMN Pro™ Complete Powder also includes micronized trans-resveratrol, which activates sirtuin signaling that relies on adequate NAD+ to function. It might help optimize how cells respond to stress, manage inflammatory signaling, and regulate metabolic activity. Micronization increases the surface area of resveratrol particles, which may improve absorption in the digestive tract and support more consistent systemic availability.
The formula also combines TMG (trimethylglycine), which could support methylation that helps regulate gene expression, detoxification, and neurotransmitter synthesis. It might also help maintain normal cellular communication and support the metabolic pathways involved in energy production and tissue maintenance.
As per the official website, Calcium AKG Longevity contains calcium alpha-ketoglutarate (Ca-AKG) that combines the mineral calcium with alpha-ketoglutarate, a naturally occurring molecule in human metabolism. This formula provides a substrate that cells can use to support ongoing energy production and metabolic efficiency, as these processes become less efficient with age, by supplying AKG in a stable, calcium-bound form.
Alpha-ketoglutarate helps shuttle nitrogen between tissues and supports the synthesis of important amino acids, which contribute to muscle maintenance, tissue repair, and metabolic stability. The calcium present in this formulation may contribute to structural and signaling functions in the body. It also acts as a signaling ion that regulates muscle contraction, nerve transmission, and heart rhythm. When paired with AKG, calcium supports skeletal integrity while also participating in the cellular processes that coordinate muscle and cardiovascular function.
NMN Pro™ Powder is formulated to support physical endurance, muscle strength, and metabolic markers. It contains Uthever® B-Nicotinamide Mononucleotide (NMN), which may support mitochondrial activity.
According to the official website, NMN Pro™ Powder can affect how cells respond to stress and how efficiently damaged components are repaired. These processes are connected to neurological function, metabolic regulation, and the maintenance of tissues over time. It focuses on supporting the biological systems that depend on NAD+, including energy metabolism, cardiovascular function, and cellular maintenance.
NMN Pro 1000 is built around Uthever® B-Nicotinamide Mononucleotide (NMN) that the body uses to produce NAD+, a coenzyme required for energy metabolism, DNA repair, and cellular signaling. NAD+ levels decline with age, which affects how efficiently cells generate energy and regulate stress-response pathways.
After absorption, NMN is converted into NAD+ through the NAD+ salvage pathway. This process supports mitochondrial function, which is central to how muscle and heart cells produce ATP. Improved mitochondrial activity is also linked to more stable metabolic output, which helps explain NMN’s association with muscle strength, cardiovascular function, and overall energy use at the cellular level. As per the official website, the NMN Pro 1000 formula is also available in strengths like 500mg and 300mg per bottle.
Trans-Resveratrol Plus may support mitochondrial activity, vascular function, and cellular antioxidant systems. The official site mentions that it contains 99.5% pure trans-resveratrol from Veri-te®.
Trans-resveratrol is a polyphenol that interacts with cellular stress-response and metabolic signaling pathways, particularly those involved in mitochondrial function and blood vessel health. It influences enzymes that regulate how efficiently cells use oxygen and nutrients to generate energy, which is closely tied to how tissues age and recover from stress. Resveratrol also affects endothelial cells that line blood vessels.
According to the official website, the proprietary blend in Trans-Resveratrol Plus adds quercetin, organic red wine extract, and organic green tea leaf extract, which contain plant-based polyphenols that interact with antioxidant and inflammatory pathways.
Quercetin helps regulate cellular transporters and enzymes involved in oxidative balance, while red wine and green tea extracts provide additional flavonoids and catechins that support mitochondrial integrity and cellular defense systems.
The formula also includes bioperine®, which inhibits certain digestive and liver enzymes that break down polyphenols too quickly. This can increase their time in circulation and their exposure to target tissues.
Pure Trans-Resveratrol Micronized Powder could support brain function, DNA maintenance, metabolic regulation, and age-related cellular health. It is formulated with Veri-te® pure trans-resveratrol, a standardized and highly purified form of the biologically active resveratrol isomer. Trans-resveratrol affects mitochondrial activity and blood vessel function, both of which are important for supplying neurons with oxygen and glucose.
As per the official website, Pure Trans-Resveratrol Micronized Powder may also support the function of endothelial cells that line blood vessels, which regulate blood flow and oxygen and nutrient delivery to tissues such as the heart and joints. The micronized form of this powder increases the surface area of resveratrol particles, which can improve dispersion and absorption in the digestive tract.
According to the official website, TMG Pro maintains normal structure and metabolic function over time. It is formulated with trimethylglycine, a naturally occurring compound involved in the body’s methylation system.
TMG Pro could help maintain homocysteine within a normal range, which supports vascular health and stable circulation. It may also help sustain methyl balance, which influences how efficiently the liver handles oxidative byproducts and lipid transport.
Methylation affects DNA stability, membrane structure, and the synthesis of compounds such as creatine and phosphatidylcholine. These processes are tied to cell integrity, energy metabolism, and membrane fluidity.
ProHealth has operated since 1988, giving it more than three decades in the supplement industry. The brand started with a broad fitness focus and adapted as research on aging advanced. Over time, it shifted its mission toward longevity and healthspan support.
As longevity science gained traction, ProHealth aligned its products with cellular and metabolic health. The portfolio now emphasizes areas such as NAD⁺ pathways through NMN, mitochondrial function, metabolic formulas, and blends positioned around DNA repair. This progression reflects gradual adaptation to evolving research rather than a sudden rebrand.
This promotes access to longevity-focused products from a brand shaped by long-term exposure to regulatory, scientific, and market shifts. The gradual evolution of ProHealth’s portfolio may reduce uncertainty associated with newly formed longevity brands that lack historical context. Products aligned with cellular and metabolic health allow you to engage with aging-related nutrition concepts in a targeted manner, rather than relying on broad wellness formulations. This positioning supports a more deliberate approach to long-term health planning, particularly if you are seeking products that reflect ongoing research trends without abrupt changes in brand direction or product philosophy.
ProHealth claims involvement from Richard Kaszynski, who works in longevity and cellular aging. The brand claims its role supports ingredient evaluation tied to metabolic health and NAD⁺ pathways. Its input is claimed to focus on relevance and application rather than leading clinical trials.
The brand also claims guidance from Joseph Maroon, a practicing neurosurgeon with experience advising nutrition companies. ProHealth claims its perspective informs decisions around product quality, safety considerations, and long-term health relevance.
Beyond named advisors, the brand also claims to extend expert support through its Nutrition Advisor program. The program is claimed to connect you with credentialed specialists who offer guidance on longevity options. This service claims to help translate scientific context into practical use.
ProHealth builds its products around well-known longevity pathways such as NAD+ support, mitochondrial health, and cellular aging. It uses ingredients like NMN, resveratrol, quercetin, and senolytics at defined doses. The brand also emphasizes purity testing and manufacturing controls.
Most scientific support comes from studies on individual ingredients, not on ProHealth’s finished products. Research shows that NMN can raise NAD+ levels, or that resveratrol affects sirtuin activity when tested on its own. These studies do not test ProHealth’s exact formulas, ingredient combinations, or delivery methods in controlled human trials. There is no public evidence of controlled human trials evaluating ProHealth’s exact formulas, ingredient synergies, or delivery methods.
This means the brand’s claims rely on general longevity research rather than direct clinical validation of its specific products. The real-world effectiveness of particular dose combinations, ingredient interactions, and absorption from the final delivery format remains untested independently.
As per their official website, Thorne highlights an extensive range of products across categories such as amino acids, multivitamins, sports performance, cognition, sleep, and women’s and men’s health. Meanwhile, ProHealth presents formulations that are framed primarily around longevity, aging over 40, and cellular health, led by NMN, resveratrol, and Ca-AKG formulas.
Thorne integrates products with multiple diagnostic options, including lab blood draws and at-home saliva, stool, and blood-spot tests for biological age, gut health, sleep, stress, and weight management. ProHealth also offers direct-to-consumer testing through its TruMe Biological Age Test, a saliva-based DNA methylation epigenetic test designed to measure biological aging at home, but its testing portfolio is narrower and more tightly centered on longevity tracking rather than multi-system fitness profiling.
Product design also differs in emphasis. Thorne’s catalog includes conventional nutrients and functional blends such as magnesium glycinate, iron bisglycinate, omega-3 with CoQ10, creatine, whey protein isolate, prenatal and 50+ multivitamins, which target specific fitness needs like heart, bone, sleep, or sports performance. ProHealth’s lineup is more tightly focused around anti-aging pathways, with multiple NMN strengths (300 mg, 500 mg, 1000 mg, and powders), Uthever® NMN, trans-resveratrol, TMG, and calcium AKG positioned around NAD+ support, DNA repair, and mitochondrial function.
Manufacturing and quality messaging are another clear divider. Thorne highlights a vertically integrated model with a 549,000-square-foot U.S. campus, four rounds of in-house testing, more than 100,000 tests per year, NSF Certified for Sport®, TGA GMP certification, and a “No List” of over 60 banned excipients. Meanwhile, ProHealth highlights FDA registration, GMP manufacturing, U.S. manufacturing and lab testing, and third-party testing for purity and potency, but without the same level of disclosed internal testing volume or regulatory certifications.
Thorne focuses on a comprehensive, diagnostics-supported approach with heavy investment in manufacturing controls, regulatory compliance, and clinical validation. On the other hand, ProHealth prioritizes NMN-centered protocols, aging-related pathways, and subscription-driven access to anti-aging formulations.
Wonderfeel centers its brand around a narrow NMN-focused portfolio, offering Youngr™ NMN (900 mg) and NMN Capsuls™ (1000 mg). On the other hand, ProHealth offers a broad longevity range with 170+ products covering NMN, resveratrol, TMG, Ca-AKG, collagen, magnesium, berberine, and related categories.
The brand Wonderfeel presents NMN as its primary intervention for NAD+ support, whereas ProHealth treats NMN as one component within a wider longevity framework, offering it in capsule, powder, liposomal, and lozenge forms.
Wonderfeel’s Youngr™ combines NMN with ergothioneine, hydroxytyrosol, resveratrol, and vitamin D3 to support NMN stability and cellular uptake. Meanwhile, ProHealth separates these functions across individual and combination products, such as NMN Pro™, Trans-Resveratrol Plus, and TMG Pro.
Wonderfeel relies on a patented, multi-ingredient NMN formulation. ProHealth uses a modular product structure, allowing you to select single-ingredient or stacked formats depending on your protocol. Wonderfeel offers fixed NMN dosages of 900 mg and 1000 mg per day. On the other hand, ProHealth provides multiple dose tiers from 300 mg to 1000 mg, positioned for different age groups and usage goals.
Wonderfeel prices its products, such as Youngr™ NMN, at around $73-$80 per month on subscription and $88 for a one-time purchase. ProHealth applies roughly 30% Subscribe & Save discounts across its NMN range, placing products such as NMN Pro™ 300 at $25.20, NMN Pro™ 500 at $39.90, and NMN Pro™ 1000 at $69.97, compared with one-time prices ranging from $36.00 to $99.95. Wonderfeel is structured around NMN-focused formulations, while ProHealth operates as a broader longevity platform covering cellular, metabolic, and cognitive support categories.
ProHealth operates in the longevity space with a catalog that focuses on aging, cellular health, metabolism, and NAD+ support. Its offerings include science-positioned formulations such as NMN, resveratrol, TMG, and related compounds marketed for mitochondrial, DNA, and healthy aging support, which reflects a long-term support model.
We also considered ProHealth’s A+ rating with the Better Business Bureau as part of this assessment. This rating provides insight into the company’s business practices, including responsiveness to customer complaints, dispute resolution processes, and operational transparency. It does not, however, evaluate the clinical efficacy, safety, or real-world effectiveness of the brand’s products.
We evaluated ProHealth using Trustpilot feedback, where the brand holds a 2.5-star rating from 25+ reviews, highlighting mixed user experiences. Many customers describe delayed or missing deliveries, especially for shipments, along with limited or slow responses to emails and messages. Several users also report unexpected subscription charges, difficulty canceling orders, and unclear shipping or tracking details. Customs fees, taxes, and delivery timelines are recurring concerns, with some stating that these costs were not clearly communicated before purchase.
Several customers mention receiving products close to their expiration date or raising questions about product condition, such as unusual appearance or smell. In many of these cases, ProHealth eventually offered refunds, replacements, or reshipments, but the delays and need for repeated follow-ups contributed to dissatisfaction and uncertainty around quality control and order handling.
On the other hand, some long-term users report steady results in areas like energy and focus, and several highlight ProHealth’s Certificates of Analysis (COAs), clear labeling, and clinically referenced dosages.
Our evaluation suggests that many customers find the brand credible, alongside areas where service delivery appears inconsistent. While formulation transparency supports trust, recurring concerns around communication, shipping, and subscriptions continue to influence customer perception.
ProHealth operates within the longevity and cellular-aging category. Its product portfolio centers on NMN, NAD⁺ support, mitochondrial function, and DNA-related pathways, delivered through both single-ingredient products and multi-ingredient formulas.
These products’ benefits are based on published research on ingredients such as NMN, resveratrol, and TMG, which have documented roles in NAD⁺ metabolism and mitochondrial function. However, the brand does not provide independent clinical trials on its finished products, so the supporting evidence remains based on ingredient-level research rather than direct testing of ProHealth’s specific formulations.
Before considering the brand and its offerings, it is important to account for potential interactions between NAD⁺ precursors and certain medications, including those that affect blood sugar, blood pressure, or liver metabolism. These compounds also influence pathways involved in methylation and energy production. Due to this, following labeled dosing and seeking professional guidance remains relevant when evaluating ongoing use.
Contact us at [email protected] or follow @leafsnap on Twitter! View our Privacy Policy.
